Tbio LAMP3 Lysosome-associated membrane glycoprotein 3

Protein Summary

Description

May play a role in dendritic cell function and in adaptive immunity. Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

Uniprot Accession IDs

• Q9UQV4
• D3DNS4
• O94781
• Q8NEC8
• LAMP-3

Gene Name

• LAMP3

Ensembl ID

• ENST00000265598
• ENSP00000265598
• ENSG00000078081

Symbol

• DCLAMP
• TSC403
• LAMP
• CD208
• DCLAMP
• LAMP-3
• TSC403
• DC LAMP
• DC-LAMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.81
small molecule perturbation	0.64
cellular component	0.57
PubMedID	0.56

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 3

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.09   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 498   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.09   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0