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Tbio
SCML2
Sex comb on midleg-like protein 2

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251900
  • ENSP00000251900
  • ENSG00000102098
  • ENST00000398048
  • ENSP00000381126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
histone modification site profile
0.75
protein domain
0.73
small molecule perturbation
0.56
cellular component
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (107)
1 – 10 of 107
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.999999184
p_ni: 8.04e-7
p_wrong: 1.2e-8
Data Source: BioPlex
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.976
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.01943349
Score: 0.975
Data Source: STRINGDB
BMI1
Tbio
Novelty: 0.00158043
Score: 0.969
Data Source: STRINGDB
CBX8
Tchem
Family: Epigenetic
Novelty: 0.00205993
Score: 0.961
Data Source: STRINGDB
CBX4
Tchem
Family: Epigenetic
Novelty: 0.02681197
Score: 0.953
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.947
Data Source: STRINGDB
EED
Tchem
Novelty: 0.00615758
Score: 0.947
Data Source: STRINGDB
CBX6
Tchem
Family: Epigenetic
Novelty: 0.08868575
Score: 0.946
Data Source: STRINGDB
PHC3
Tbio
Novelty: 0.00091911
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.17

PubMed score by year
PubTator Score  11.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer