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Tbio
SCML2
Sex comb on midleg-like protein 2

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251900
  • ENSP00000251900
  • ENSG00000102098
  • ENST00000398048
  • ENSP00000381126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
histone modification site profile
0.75
protein domain
0.73
small molecule perturbation
0.56
cellular component
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Scm polycomb group protein like 2
694404
Dog
Scm polycomb group protein like 2
VGNC:45911
480855
Horse
Scm polycomb group protein like 2
VGNC:22729
100057593
Cow
Scm polycomb group protein like 2
VGNC:34341
523477
Pig
Scm polycomb group protein like 2
100519636
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Scm polycomb group protein like 2
Dog
Scm polycomb group protein like 2
Horse
Scm polycomb group protein like 2
Cow
Scm polycomb group protein like 2
Pig
Scm polycomb group protein like 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UQR0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (107)
1 – 10 of 107
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.999999184
p_ni: 8.04e-7
p_wrong: 1.2e-8
Data Source: BioPlex
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.976
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.01943349
Score: 0.975
Data Source: STRINGDB
BMI1
Tbio
Novelty: 0.00158043
Score: 0.969
Data Source: STRINGDB
CBX8
Tchem
Family: Epigenetic
Novelty: 0.00205993
Score: 0.961
Data Source: STRINGDB
CBX4
Tchem
Family: Epigenetic
Novelty: 0.02681197
Score: 0.953
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.947
Data Source: STRINGDB
EED
Tchem
Novelty: 0.00615758
Score: 0.947
Data Source: STRINGDB
CBX6
Tchem
Family: Epigenetic
Novelty: 0.08868575
Score: 0.946
Data Source: STRINGDB
PHC3
Tbio
Novelty: 0.00091911
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.17

PubMed score by year
PubTator Score  11.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer