Tbio SH2B3 SH2B adapter protein 3

Protein Summary

Description

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q9UQQ2
• B9EGG5
• O95184

Gene Name

• SH2B3

Ensembl ID

• ENST00000341259
• ENSP00000345492
• ENSG00000111252

Symbol

• LNK
• LNK
• IDDM20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
transcription factor binding site profile	0.93
kinase perturbation	0.88
disease perturbation	0.87
transcription factor	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.47   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.47   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0