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Tbio
NAALADL1
N-acetylated-alpha-linked acidic dipeptidase-like protein

Protein Classes
Protein Summary
Description
NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340252
  • ENSP00000344244
  • ENSG00000168060
  • ENST00000355721
  • ENSP00000347955
  • ENST00000358658
  • ENSP00000351484

Symbol
  • NAALADASEL
  • NAALADL
  • I100
  • NAALADASEL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
tissue sample
0.6
cell line
0.54
tissue
0.46
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
18.2
metabolic syndrome
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
18.2
metabolic syndrome
1
3.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylated alpha-linked acidic dipeptidase like 1
VGNC:48936
451309
Macaque
N-acetylated alpha-linked acidic dipeptidase like 1
717018
Mouse
MGI:2685810
381204
Rat
RGD:620987
83568
Horse
N-acetylated alpha-linked acidic dipeptidase like 1
VGNC:20536
100056368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylated alpha-linked acidic dipeptidase like 1
Macaque
N-acetylated alpha-linked acidic dipeptidase like 1
Mouse
Rat
Horse
N-acetylated alpha-linked acidic dipeptidase like 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UQQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
DPP4
Tclin
Family: Enzyme
Novelty: 0.00017047
Score: 0.743
Data Source: STRINGDB
UCHL1
Tchem
Family: Enzyme
Novelty: 0.00056075
Score: 0.73
Data Source: STRINGDB
ADGRG6
Tbio
Family: GPCR
Novelty: 0.01186813
Score: 0.726
Data Source: STRINGDB
CCR7
Tbio
Family: GPCR
Novelty: 0.00084453
Score: 0.713
Data Source: STRINGDB
KCNN3
Tchem
Family: IC
Novelty: 0.00227544
Score: 0.706
Data Source: STRINGDB
CD27
Tbio
Novelty: 0.00090508
Score: 0.682
Data Source: STRINGDB
IL7R
Tbio
Novelty: 0.00107223
Score: 0.669
Data Source: STRINGDB
CD19
Tclin
Novelty: 0.0001816
Score: 0.66
Data Source: STRINGDB
CD38
Tclin
Family: Enzyme
Novelty: 0.00034991
Score: 0.64
Data Source: STRINGDB
INSM2
Tbio
Family: TF
Novelty: 0.01167787
Score: 0.633
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.35

PubMed score by year
PubTator Score  3.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer