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Tbio
TNN
Tenascin-N

Protein Summary
Description
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239462
  • ENSP00000239462
  • ENSG00000120332

Symbol
  • TNW
  • TN-W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.66
cell line
0.61
cell type or tissue
0.51
microRNA
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tenascin N
VGNC:1693
469593
Macaque
tenascin N
708587
Mouse
MGI:2665790
329278
Rat
RGD:1306002
304913
Dog
tenascin N
VGNC:47685
490335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tenascin N
Macaque
tenascin N
Mouse
Rat
Dog
tenascin N
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UQP3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (51)
1 – 10 of 51
ACAN
Tbio
Novelty: 0.00033695
Score: 0.975
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.917
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.915
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.904
Data Source: STRINGDB
ITGA8
Tbio
Novelty: 0.0220023
Score: 0.846
Data Source: STRINGDB
SDC4
Tbio
Novelty: 0.00319073
Score: 0.836
Data Source: STRINGDB
ITGA9
Tbio
Novelty: 0.01488635
Score: 0.834
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.832
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.813
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.81
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.49

PubMed score by year
PubTator Score  8.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer