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Tchem
CAMK2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348628
  • ENSP00000261793
  • ENSG00000070808
  • ENST00000398376
  • ENSP00000381412

Symbol
  • CAMKA
  • KIAA0968
  • CAMKA
  • MRD53
  • MRT63
  • CaMKIINalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.98
protein domain
0.92
phosphatase
0.9
biological process
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.02   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 813   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.02   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 813   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
3.3
46.2
1
1
0
1.1
15.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
3.3
46.2
0
1.1
15.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II alpha
VGNC:54157
462189
Mouse
MGI:88256
12322
Rat
RGD:2261
25400
Dog
calcium/calmodulin dependent protein kinase II alpha
VGNC:38680
612941
Horse
calcium/calmodulin dependent protein kinase II alpha
VGNC:16021
100071654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase II alpha
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase II alpha
Horse
calcium/calmodulin dependent protein kinase II alpha
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (123)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Beta-catenin independent WNT signaling
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Beta-catenin independent WNT signaling
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Ca-dependent events
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (315)
1 – 10 of 315
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999983562
p_ni: 0.000016438
p_wrong: 1e-9
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999962498
p_ni: 0.000037487
p_wrong: 1.5e-8
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999940355
p_ni: 0.000059644
Score: 0.161
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999716584
p_ni: 0.000283415
p_wrong: 1e-9
Data Source: BioPlex
ARMC1
Tbio
Novelty: 0.02018109
p_int: 0.997239316
p_ni: 0.002760684
Data Source: BioPlex
RRP7A
Tbio
Novelty: 0.11315285
p_int: 0.991875344
p_ni: 0.008123846
p_wrong: 8.1e-7
Score: 0.175
Data Source: BioPlex,STRINGDB
CDCA8
Tbio
Novelty: 0.01448513
p_int: 0.99115014
p_ni: 0.008849072
p_wrong: 7.89e-7
Score: 0.169
Data Source: BioPlex,STRINGDB
CAMK2B
Tchem
Family: Kinase
Novelty: 0.00793595
Score: 0.998
Data Source: Reactome,STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.04642387
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  146.02

PubMed score by year
PubTator Score  27.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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