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Tclin
HDAC5
Histone deacetylase 5

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetyla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225983
  • ENSP00000225983
  • ENSG00000108840
  • ENST00000336057
  • ENSP00000337290
  • ENST00000586802
  • ENSP00000468004

Symbol
  • KIAA0600
  • HD5
  • NY-CO-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
1
disease perturbation
0.99
hub protein
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.73   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.73   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 79
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (79)
1 – 10 of 79
CHEMBL99
chemical structure image
CHEMBL408513
chemical structure image
CHEMBL356066
chemical structure image
CHEMBL1213490
chemical structure image
CHEMBL598797
chemical structure image
CHEMBL1213492
chemical structure image
CHEMBL1851943,CHEMBL3215861
chemical structure image
CHEMBL96051
chemical structure image
CHEMBL491316
chemical structure image
CHEMBL2105763
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
97.5
bone density
1
1
1
36.8
high density lipoprotein cholesterol measurement
1
1
1
31.4
apolipoprotein A 1 measurement
1
1
1
13.5
1
1
0
1.1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
97.5
bone density
1
36.8
high density lipoprotein cholesterol measurement
1
31.4
apolipoprotein A 1 measurement
1
13.5
0
1.1
11.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (268)
1 – 10 of 268
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999999959
p_wrong: 4.1e-8
Score: 0.248
Data Source: BioPlex,STRINGDB
ANKRA2
Tbio
Novelty: 0.19358401
Score: 0.992
Data Source: STRINGDB
RFXANK
Tbio
Novelty: 0.00355465
Score: 0.985
Data Source: STRINGDB
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
Score: 0.979
Data Source: STRINGDB
MEF2A
Tbio
Family: TF
Novelty: 0.00439393
Score: 0.978
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.977
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.976
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.976
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.966
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.73

PubMed score by year
PubTator Score  137.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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