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Tclin
HDAC5
Histone deacetylase 5

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetyla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225983
  • ENSP00000225983
  • ENSG00000108840
  • ENST00000336057
  • ENSP00000337290
  • ENST00000586802
  • ENSP00000468004

Symbol
  • KIAA0600
  • HD5
  • NY-CO-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
1
disease perturbation
0.99
hub protein
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.49   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.49   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 113
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (113)
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
CUDC-101
Rendered image for CUDC-101
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
abexinostat
Rendered image for abexinostat
dacinostat
Rendered image for dacinostat
givinostat
Rendered image for givinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
Protein-Protein Interactions (268)
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999999959
p_wrong:  4.1e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
ANKRA2
Tbio
Novelty:  0.19358401
Score:  0.992
Data Source:  STRINGDB
RFXANK
Tbio
Novelty:  0.00355465
Score:  0.985
Data Source:  STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.979
Data Source:  STRINGDB
MEF2A
Tbio
Family:  TF
Novelty:  0.00439393
Score:  0.978
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.977
Data Source:  STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.976
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.976
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.966
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.8
HbA1c measurement
2
2
2
94.3
femoral neck bone mineral density
1
1
1
89.7
bone density
2
3
4
84.8
body fat percentage
1
1
1
64.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.8
HbA1c measurement
2
94.3
femoral neck bone mineral density
1
89.7
bone density
4
84.8
body fat percentage
1
64.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 5
VGNC:9316
454721
Macaque
histone deacetylase 5
711456
Mouse
MGI:1333784
15184
Rat
RGD:619980
84580
Dog
histone deacetylase 5
VGNC:49093
490941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 5
Macaque
histone deacetylase 5
Mouse
Rat
Dog
histone deacetylase 5
Publication Statistics
PubMed Score 235.49
PubMed score by year
PubTator Score 137.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Text