Tbio PPP1R3C Protein phosphatase 1 regulatory subunit 3C

Protein Summary

Description

Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9UQK1
• B2R7X0
• O95686

Gene Name

• PPP1R3C

Ensembl ID

• ENST00000238994
• ENSP00000238994
• ENSG00000119938

Symbol

• PPP1R5
• PTG
• PPP1R5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
small molecule perturbation	0.96
disease perturbation	0.83
virus perturbation	0.76
PubMedID	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Subunit 3c

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Subunit 3c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.72   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0