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Tbio
MAPK8IP1
C-Jun-amino-terminal kinase-interacting protein 1

Protein Summary
Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, M ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241014
  • ENSP00000241014
  • ENSG00000121653

Symbol
  • IB1
  • JIP1
  • PRKM8IP
  • IB1
  • JIP1
  • JIP-1
  • PRKM8IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.93
hub protein
0.88
molecular function
0.81
biological process
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.53   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.53   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
TTLL4
Tbio
Family:  Enzyme
Novelty:  0.14127442
p_int:  0.999999961
p_ni:  3.7e-8
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
p_int:  0.999999244
p_ni:  6.87e-7
p_wrong:  6.9e-8
Score:  0.972
Data Source:  BioPlex,STRINGDB
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.999997159
p_ni:  0.000002841
Score:  0.223
Data Source:  BioPlex,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
p_int:  0.999930947
p_ni:  0.000066838
p_wrong:  0.000002215
Score:  0.997
Data Source:  BioPlex,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.999829924
p_ni:  0.000170076
Score:  0.983
Data Source:  BioPlex,STRINGDB
MAPK8IP3
Tbio
Family:  Enzyme
Novelty:  0.01127812
p_int:  0.999753312
p_ni:  0.000246688
Score:  0.944
Data Source:  BioPlex,STRINGDB
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.99918993
p_ni:  0.00081007
Data Source:  BioPlex
HOXC8
Tbio
Family:  TF
Novelty:  0.01042291
p_int:  0.99560903
p_wrong:  0.00439097
Score:  0.379
Data Source:  BioPlex,STRINGDB
ANK2
Tbio
Novelty:  0.00528351
p_int:  0.992460769
p_ni:  0.007539231
Score:  0.284
Data Source:  BioPlex,STRINGDB
SENP5
Tbio
Family:  Enzyme
Novelty:  0.0510532
p_int:  0.980890251
p_ni:  0.019109748
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
2
2
91.9
high density lipoprotein cholesterol measurement
3
2
3
87.5
fasting blood glucose measurement
6
1
6
77.9
3
3
2
1
71.4
body mass index
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
91.9
high density lipoprotein cholesterol measurement
3
87.5
fasting blood glucose measurement
6
77.9
2
1
71.4
body mass index
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 1
VGNC:7508
451148
Macaque
mitogen-activated protein kinase 8 interacting protein 1
714950
Mouse
MGI:1309464
19099
Rat
RGD:70937
116457
Dog
mitogen-activated protein kinase 8 interacting protein 1
VGNC:49920
483640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 1
Macaque
mitogen-activated protein kinase 8 interacting protein 1
Mouse
Rat
Dog
mitogen-activated protein kinase 8 interacting protein 1
Publication Statistics
PubMed Score 360.53
PubMed score by year
PubTator Score 655.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title