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Tbio
SMC3
Structural maintenance of chromosomes protein 3

Protein Summary
Description
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361804
  • ENSP00000354720
  • ENSG00000108055

Symbol
  • BAM
  • BMH
  • CSPG6
  • SMC3L1
  • BAM
  • BMH
  • HCAP
  • CDLS3
  • CSPG6
  • SMC3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
molecular function
0.98
protein complex
0.98
transcription factor binding site profile
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
4.6
Sepsis
1
1
0
1.7
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
4.6
Sepsis
0
1.7
4.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 3
VGNC:5786
450731
Macaque
structural maintenance of chromosomes 3
695123
Mouse
MGI:1339795
13006
Rat
RGD:62006
29486
Dog
structural maintenance of chromosomes 3
VGNC:46544
486886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 3
Macaque
structural maintenance of chromosomes 3
Mouse
Rat
Dog
structural maintenance of chromosomes 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UQE7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (417)
1 – 10 of 417
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.999910763
p_ni: 0.000089237
Score: 0.999
Data Source: BioPlex,STRINGDB
REC8
Tbio
Novelty: 0.00732742
p_int: 0.999497048
p_ni: 0.000502952
Score: 0.998
Data Source: BioPlex,STRINGDB
PSMC2
Tbio
Family: Enzyme
Novelty: 0.08240664
p_int: 0.982435708
p_ni: 0.017564292
Score: 0.755
Data Source: BioPlex,STRINGDB
CDCA5
Tbio
Novelty: 0.02255012
p_int: 0.871550176
p_ni: 0.128449824
Score: 0.997
Data Source: BioPlex,STRINGDB
SDF4
Tbio
Novelty: 0.00105893
p_int: 0.809819797
p_ni: 0.190180203
Score: 0.175
Data Source: BioPlex,STRINGDB
PDS5A
Tbio
Novelty: 0.0142948
Score: 0.999
Data Source: STRINGDB
WAPL
Tbio
Novelty: 0.01598061
Score: 0.999
Data Source: STRINGDB
STAG1
Tbio
Novelty: 0.00122511
Score: 0.999
Data Source: STRINGDB
ESCO1
Tbio
Family: Enzyme
Novelty: 0.01447283
Score: 0.999
Data Source: STRINGDB
PDS5B
Tbio
Novelty: 0.00295057
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.69

PubMed score by year
PubTator Score  230.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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