SMC3
Structural maintenance of chromosomes protein 3
Protein Summary
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the s ...more
- ENST00000361804
- ENSP00000354720
- ENSG00000108055
- BAM
- BMH
- CSPG6
- SMC3L1
- BAM
- BMH
- HCAP
- CDLS3
- CSPG6
- SMC3L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
hub protein | 0.99 | ||
molecular function | 0.98 | ||
protein complex | 0.98 | ||
transcription factor binding site profile | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.7 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 293 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.7 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 293 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (417)
RAD21
Novelty: 0.00270936
p_int: 0.999910763
p_ni: 0.000089237
Score: 0.999
Data Source: BioPlex,STRINGDB
REC8
Novelty: 0.00732742
p_int: 0.999497048
p_ni: 0.000502952
Score: 0.998
Data Source: BioPlex,STRINGDB
PSMC2
Family: Enzyme
Novelty: 0.08240664
p_int: 0.982435708
p_ni: 0.017564292
Score: 0.755
Data Source: BioPlex,STRINGDB
CDCA5
Novelty: 0.02255012
p_int: 0.871550176
p_ni: 0.128449824
Score: 0.997
Data Source: BioPlex,STRINGDB
SDF4
Novelty: 0.00105893
p_int: 0.809819797
p_ni: 0.190180203
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (24)
KEGG (2)
PathwayCommons (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cohesin Loading onto Chromatin | ||||
Reactome | ESR-mediated signaling | ||||
Reactome | Establishment of Sister Chromatid Cohesion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cohesin Loading onto Chromatin | ||||
ESR-mediated signaling | ||||
Establishment of Sister Chromatid Cohesion | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (7)
Components (14)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 71.9 | |||||
electrocardiography | 1 | 1 | 3 | 47.7 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 24.5 | |||||
bone density | 1 | 1 | 1 | 17.8 | |||||
acute respiratory distress syndrome | 1 | 1 | 0 | 1.7 | 0.4 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 71.9 | |||||
electrocardiography | 3 | 47.7 | |||||
serum non-albumin protein measurement | 1 | 24.5 | |||||
bone density | 1 | 17.8 | |||||
acute respiratory distress syndrome | 0 | 1.7 | 0.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | structural maintenance of chromosomes 3 | VGNC:5786 | 450731 | |||||
Macaque | structural maintenance of chromosomes 3 | 695123 | ||||||
Mouse | MGI:1339795 | 13006 | ||||||
Rat | RGD:62006 | 29486 | ||||||
Dog | structural maintenance of chromosomes 3 | VGNC:46544 | 486886 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | structural maintenance of chromosomes 3 | |||||
Macaque | structural maintenance of chromosomes 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | structural maintenance of chromosomes 3 | |||||
Publication Statistics
PubMed Score 197.70
PubMed score by year
PubTator Score 230.85
PubTator score by year
Related Publications
Text Mined References (70)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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