Tbio SMC3 Structural maintenance of chromosomes protein 3

Protein Summary

Description

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UQE7
• A8K156
• O60464
• Q5T482
• SMC protein 3

Gene Name

• SMC3

Ensembl ID

• ENST00000361804
• ENSP00000354720
• ENSG00000108055

Symbol

• BAM
• BMH
• CSPG6
• SMC3L1
• BAM
• BMH
• HCAP
• CDLS3
• CSPG6
• SMC3L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.99
molecular function	0.98
protein complex	0.98
transcription factor binding site profile	0.92

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
acute respiratory distress syndrome	EFO_1000637	1	1	0	1.7	4.6
Sepsis	HP_0100806	1	1	0	1.7	4.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
acute respiratory distress syndrome	EFO_1000637	0	1.7	4.6
Sepsis	HP_0100806	0	1.7	4.6

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	structural maintenance of chromosomes 3	VGNC:5786	450731
Macaque	structural maintenance of chromosomes 3		695123
Mouse	structural maintenance of chromosomes 3	MGI:1339795	13006
Rat	structural maintenance of chromosomes 3	RGD:62006	29486
Dog	structural maintenance of chromosomes 3	VGNC:46544	486886

Species	Name	OMA	EggNOG	Inparanoid
Chimp	structural maintenance of chromosomes 3
Macaque	structural maintenance of chromosomes 3
Mouse	structural maintenance of chromosomes 3
Rat	structural maintenance of chromosomes 3
Dog	structural maintenance of chromosomes 3

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9UQE7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)

Reactome (24)

KEGG (2)

PathwayCommons (2)

WikiPathways (6)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cohesin Loading onto Chromatin	10 targets	R-HSA-2470946
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Establishment of Sister Chromatid Cohesion	11 targets	R-HSA-2468052

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cohesin Loading onto Chromatin	10 targets	R-HSA-2470946
ESR-mediated signaling	189 targets	R-HSA-8939211
Establishment of Sister Chromatid Cohesion	11 targets	R-HSA-2468052

Gene Ontology Terms (32)

Functions (7)

Components (14)

Processes (11)

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1 – 7 of 7

GO Term	Evidence	Assigned by
beta-tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB
dynein complex binding	Inferred from Direct Assay (IDA)	UniProtKB
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
microtubule motor activity	Non-traceable Author Statement (NAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl
mediator complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (417)

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1 – 10 of 417

• See Interactions on String-DB

RAD21

Tbio

Novelty: 0.00270936

p_int: 0.999910763

p_ni: 0.000089237

Score: 0.999

Data Source: BioPlex,STRINGDB

REC8

Tbio

Novelty: 0.00732742

p_int: 0.999497048

p_ni: 0.000502952

Score: 0.998

Data Source: BioPlex,STRINGDB

PSMC2

Tbio

Family: Enzyme

Novelty: 0.08240664

p_int: 0.982435708

p_ni: 0.017564292

Score: 0.755

Data Source: BioPlex,STRINGDB

CDCA5

Tbio

Novelty: 0.02255012

p_int: 0.871550176

p_ni: 0.128449824

Score: 0.997

Data Source: BioPlex,STRINGDB

SDF4

Tbio

Novelty: 0.00105893

p_int: 0.809819797

p_ni: 0.190180203

Score: 0.175

Data Source: BioPlex,STRINGDB

PDS5A

Tbio

Novelty: 0.0142948

Score: 0.999

Data Source: STRINGDB

WAPL

Tbio

Novelty: 0.01598061

Score: 0.999

Data Source: STRINGDB

STAG1

Tbio

Novelty: 0.00122511

Score: 0.999

Data Source: STRINGDB

ESCO1

Tbio

Family: Enzyme

Novelty: 0.01447283

Score: 0.999

Data Source: STRINGDB

PDS5B

Tbio

Novelty: 0.00295057

Score: 0.999

Data Source: STRINGDB

Publication Statistics

PubMed Score  192.69

PubMed score by year

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PubTator Score  230.85

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
ATP-binding
Cell cycle
Cell division
Centromere
Chromosome
Coiled coil
Complete proteome
Disease mutation
DNA damage

GWAS Trait Find Similar Targets

acute respiratory distress syndrome
Sepsis

MGI Phenotype Find Similar Targets

adipose tissue phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
mortality/aging
pigmentation phenotype
skeleton phenotype