Tclin SCN8A Sodium channel protein type 8 subunit alpha

Protein Summary

Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9UQD0
• B9VWG8
• O95788
• Q9NYX2
• Q9UPB2

Gene Name

• SCN8A

Ensembl ID

• ENST00000354534
• ENSP00000346534
• ENSG00000196876
• ENST00000355133
• ENSP00000347255
• ENST00000545061
• ENSP00000440360
• ENST00000599343
• ENSP00000476447
• ENST00000627620
• ENSP00000487583

Symbol

• MED
• MED
• PN4
• CIAT
• BFIS5
• NaCh6
• CERIII
• EIEE13
• MYOCL2
• Nav1.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.92
cellular component	0.76
histone modification site profile	0.75
transcription factor	0.7

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 8 Subunit Alpha

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 8 Subunit Alpha

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 8 Subunit Alpha

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 8 Subunit Alpha

DTO Classes

Protein / Ion Channel / Sodium Channel Family / Nav1.6/scn8a Subfamily / Sodium Channel Protein Type 8 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.66   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.66   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13