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Tbio
CLCA2
Calcium-activated chloride channel regulator 2

Protein Summary
Description
Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370565
  • ENSP00000359596
  • ENSG00000137975

Symbol
  • CACC3
  • CACC
  • CACC3
  • CLCRG2
  • CaCC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.82
transcription factor perturbation
0.74
kinase perturbation
0.66
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.41   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.41   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
NDC1
Tbio
Novelty:  0.15840853
p_int:  0.955753253
p_ni:  0.044246747
Score:  0.252
Data Source:  BioPlex,STRINGDB
CLCA4
Tbio
Family:  IC
Novelty:  0.05891943
Score:  0.91
Data Source:  STRINGDB
CLCA1
Tbio
Family:  IC
Novelty:  0.01111462
Score:  0.907
Data Source:  STRINGDB
ESAM
Tbio
Novelty:  0.00462452
Score:  0.751
Data Source:  STRINGDB
KCTD20
Tdark
Novelty:  0.47655751
Score:  0.682
Data Source:  STRINGDB
PRR16
Tdark
Novelty:  0.17809341
Score:  0.641
Data Source:  STRINGDB
ITGB4
Tbio
Novelty:  0.00386461
Score:  0.53
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.522
Data Source:  STRINGDB
DSC3
Tbio
Novelty:  0.00457331
Score:  0.5
Data Source:  STRINGDB
KCNK17
Tchem
Family:  IC
Novelty:  0.04038829
Score:  0.488
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
40.7
Hallux valgus
1
1
0
2.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
40.7
Hallux valgus
0
2.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride channel accessory 2
VGNC:501
736939
Macaque
chloride channel accessory 2
711959
Mouse
MGI:2139758
229933
Rat
RGD:1304894
308016
Dog
chloride channel accessory 2
VGNC:39297
612510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride channel accessory 2
Macaque
chloride channel accessory 2
Mouse
Rat
Dog
chloride channel accessory 2
Publication Statistics
PubMed Score 39.41
PubMed score by year
PubTator Score 30.28
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title