Tbio CLCA2 Calcium-activated chloride channel regulator 2

Protein Summary

Description

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9UQC9
• A8K2T3
• Q9Y6N2

Gene Name

• CLCA2

Ensembl ID

• ENST00000370565
• ENSP00000359596
• ENSG00000137975

Symbol

• CACC3
• CACC
• CACC3
• CLCRG2
• CaCC-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
gene perturbation	0.82
transcription factor perturbation	0.74
kinase perturbation	0.66
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Calcium-activated Chloride Channel Regulator 2

Protein / ... / Metalloprotease / Calcium-activated Chloride Channel Regulator 2

DTO Classes

Protein / Ion Channel / Epithelial Chloride Channel (E-clc) Family / Calcium-activated Chloride Channel Regulator 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0