Tbio GAB2 GRB2-associated-binding protein 2

Protein Summary

Description

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9UQC2
• A2RRM2
• A6NEW9
• A7MD36
• O60317

Gene Name

• GAB2

Ensembl ID

• ENST00000340149
• ENSP00000343959
• ENSG00000033327
• ENST00000361507
• ENSP00000354952

Symbol

• KIAA0571

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
kinase	0.92
transcription factor binding site profile	0.9
transcription factor	0.77
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Grb2-associated-binding Protein 2

DTO Classes

Protein / Receptor / Grb2-associated-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.95   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 654   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.95   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0