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Tbio
BAIAP2
Brain-specific angiogenesis inhibitor 1-associated protein 2

Protein Summary
Description
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321280
  • ENSP00000315685
  • ENSG00000175866
  • ENST00000321300
  • ENSP00000316338
  • ENST00000428708
  • ENSP00000401022
  • ENST00000435091
  • ENSP00000413069
  • ENST00000575712
  • ENSP00000458964

Symbol
  • BAP2
  • FLAF3
  • IRSP53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
virus perturbation
0.9
hub protein
0.85
transcription factor binding site profile
0.85
transcription factor perturbation
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.87   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.87   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0