Tbio BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2

Protein Summary

Description

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9UQB8
• O43858
• Q53HB1
• Q86WC1
• Q8N5C0
• Q96CR7
• Q9UBR3
• Q9UQ43
• BAI-associated protein 2

Gene Name

• BAIAP2

Ensembl ID

• ENST00000321280
• ENSP00000315685
• ENSG00000175866
• ENST00000321300
• ENSP00000316338
• ENST00000428708
• ENSP00000401022
• ENST00000435091
• ENSP00000413069
• ENST00000575712
• ENSP00000458964

Symbol

• BAP2
• FLAF3
• IRSP53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
virus perturbation	0.9
hub protein	0.85
transcription factor binding site profile	0.85
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Receptor / Brain-specific Angiogenesis Inhibitor 1-associated Protein 2

DTO Classes

Protein / Receptor / Brain-specific Angiogenesis Inhibitor 1-associated Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.87   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 501   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.87   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0