Tbio EXO1 Exonuclease 1

Protein Summary

Description

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UQ84
• O60545
• O75214
• O75466
• Q5T396
• Q96IJ1
• Q9UG38
• Q9UNW0
• hExo1

Gene Name

• EXO1

Ensembl ID

• ENST00000348581
• ENSP00000311873
• ENSG00000174371
• ENST00000366548
• ENSP00000355506
• ENST00000518483
• ENSP00000430251

Symbol

• EXOI
• HEX1
• HEX1
• hExoI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.92
protein domain	0.85
transcription factor binding site profile	0.82
disease	0.73

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exodeoxyribonuclease / Exonuclease 1

Protein / Nucleic Acid Binding / Nuclease / Endodeoxyribonuclease / Exonuclease 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Exodeoxyribonuclease / Exonuclease 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Endodeoxyribonuclease / Exonuclease 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Damaged Dna-binding Protein / Exonuclease 1

Protein / Hydrolase / Exonuclease 1

DTO Classes

Protein / Enzyme / Nuclease / Exodeoxyribonuclease / Exonuclease 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1001.71   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 352   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1001.71   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0