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Tbio
RIMS2
Regulating synaptic membrane exocytosis protein 2

Protein Summary
Description
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262231
  • ENSP00000262231
  • ENSG00000176406
  • ENST00000339750
  • ENSP00000342051
  • ENST00000504942
  • ENSP00000427018
  • ENST00000507740
  • ENSP00000423559

Symbol
  • KIAA0751
  • RAB3IP3
  • RIM2
  • OBOE
  • RIM2
  • RAB3IP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.76
trait
0.75
disease perturbation
0.74
interacting protein
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.45   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.45   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.993
Data Source:  STRINGDB
TSPOAP1
Tbio
Novelty:  0.10247675
Score:  0.983
Data Source:  STRINGDB
RAPGEF4
Tchem
Novelty:  0.00235788
Score:  0.958
Data Source:  STRINGDB
RIMBP2
Tdark
Novelty:  0.06169893
Score:  0.925
Data Source:  STRINGDB
PCLO
Tbio
Novelty:  0.00918397
Score:  0.915
Data Source:  STRINGDB
RAB3C
Tbio
Family:  Enzyme
Novelty:  0.06291754
Score:  0.898
Data Source:  STRINGDB
RABAC1
Tbio
Novelty:  0.01749453
Score:  0.819
Data Source:  STRINGDB
UNC13A
Tbio
Novelty:  0.01009835
Score:  0.804
Data Source:  STRINGDB
TULP4
Tbio
Family:  TF
Novelty:  0.05658032
Score:  0.733
Data Source:  STRINGDB
BSN
Tbio
Novelty:  0.00468806
Score:  0.713
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
67.7
self reported educational attainment
2
2
2
61.8
disease progression measurement
1
1
0
4.7
48.5
biological sex
1
1
1
30.2
intelligence
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
67.7
self reported educational attainment
2
61.8
disease progression measurement
0
4.7
48.5
biological sex
1
30.2
intelligence
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
regulating synaptic membrane exocytosis 2
694366
Mouse
MGI:2152972
116838
Rat
RGD:620001
116839
Dog
regulating synaptic membrane exocytosis 2
VGNC:45583
475066
Cow
regulating synaptic membrane exocytosis 2
VGNC:33972
535674
Species
Name
OMA
EggNOG
Inparanoid
Macaque
regulating synaptic membrane exocytosis 2
Mouse
Rat
Dog
regulating synaptic membrane exocytosis 2
Cow
regulating synaptic membrane exocytosis 2
Publication Statistics
PubMed Score 35.45
PubMed score by year
PubTator Score 27.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title