RIMS2
Regulating synaptic membrane exocytosis protein 2
Protein Summary
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
- ENST00000262231
- ENSP00000262231
- ENSG00000176406
- ENST00000339750
- ENSP00000342051
- ENST00000504942
- ENSP00000427018
- ENST00000507740
- ENSP00000423559
- KIAA0751
- RAB3IP3
- RIM2
- OBOE
- RIM2
- RAB3IP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
transcription factor | 0.76 | ||
trait | 0.75 | ||
disease perturbation | 0.74 | ||
interacting protein | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.54 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.54 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0