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Tbio
RIMS2
Regulating synaptic membrane exocytosis protein 2

Protein Summary
Description
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262231
  • ENSP00000262231
  • ENSG00000176406
  • ENST00000339750
  • ENSP00000342051
  • ENST00000504942
  • ENSP00000427018
  • ENST00000507740
  • ENSP00000423559

Symbol
  • KIAA0751
  • RAB3IP3
  • RIM2
  • OBOE
  • RIM2
  • RAB3IP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.76
trait
0.75
disease perturbation
0.74
interacting protein
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.95   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.95   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
86.4
intelligence
1
1
0
5.6
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
86.4
intelligence
0
5.6
61.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.993
Data Source: STRINGDB
TSPOAP1
Tbio
Novelty: 0.10247675
Score: 0.983
Data Source: STRINGDB
RAPGEF4
Tchem
Novelty: 0.00235788
Score: 0.958
Data Source: STRINGDB
RIMBP2
Tdark
Novelty: 0.06169893
Score: 0.925
Data Source: STRINGDB
PCLO
Tbio
Novelty: 0.00918397
Score: 0.915
Data Source: STRINGDB
RAB3C
Tbio
Family: Enzyme
Novelty: 0.06291754
Score: 0.898
Data Source: STRINGDB
RABAC1
Tbio
Novelty: 0.01749453
Score: 0.819
Data Source: STRINGDB
UNC13A
Tbio
Novelty: 0.01009835
Score: 0.804
Data Source: STRINGDB
TULP4
Tbio
Family: TF
Novelty: 0.05658032
Score: 0.733
Data Source: STRINGDB
BSN
Tbio
Novelty: 0.00468806
Score: 0.713
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.95

PubMed score by year
PubTator Score  27.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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