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Tbio
DNM3
Dynamin-3

Protein Summary
Description
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355305
  • ENSP00000347457
  • ENSG00000197959
  • ENST00000367731
  • ENSP00000356705
  • ENST00000367733
  • ENSP00000356707
  • ENST00000627582
  • ENSP00000486701

Symbol
  • KIAA0820
  • Dyna III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.93
molecular function
0.91
transcription factor perturbation
0.84
histone modification site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.42   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.42   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999998933
p_ni:  0.000001067
Score:  0.615
Data Source:  BioPlex,STRINGDB
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.999996715
p_ni:  0.000003281
p_wrong:  3e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.999989332
p_ni:  0.000010668
Score:  0.976
Data Source:  BioPlex,STRINGDB
DNMBP
Tbio
Novelty:  0.0533946
p_int:  0.999789089
p_ni:  0.000210906
p_wrong:  5e-9
Score:  0.525
Data Source:  BioPlex,STRINGDB
DNM2
Tchem
Novelty:  0.00265965
p_int:  0.999702388
p_ni:  0.00029761
p_wrong:  2e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999513098
p_ni:  0.000486898
p_wrong:  4e-9
Data Source:  BioPlex
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.998823021
p_ni:  0.001176979
Score:  0.228
Data Source:  BioPlex,STRINGDB
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.993422741
p_ni:  0.006577258
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.992321628
p_ni:  0.007678371
p_wrong:  1e-9
Score:  0.242
Data Source:  BioPlex,STRINGDB
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.989805942
p_ni:  0.010194057
p_wrong:  1e-9
Score:  0.301
Data Source:  BioPlex,STRINGDB
Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
8
12
99.8
BMI-adjusted waist-hip ratio
12
18
45
99.3
platelet count
7
8
10
3.4
98.2
body height
5
5
4
5.4
98.1
heel bone mineral density
3
7
9
97.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
12
99.8
BMI-adjusted waist-hip ratio
45
99.3
platelet count
10
3.4
98.2
body height
4
5.4
98.1
heel bone mineral density
9
97.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dynamin 3
705300
Mouse
MGI:1341299
103967
Rat
RGD:727949
171574
Dog
dynamin 3
VGNC:40034
490341
Horse
dynamin 3
VGNC:17253
100060156
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dynamin 3
Mouse
Rat
Dog
dynamin 3
Horse
dynamin 3
Publication Statistics
PubMed Score 49.42
PubMed score by year
PubTator Score 26.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title