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Tbio
SHOC2
Leucine-rich repeat protein SHOC-2

Protein Summary
Description
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265277
  • ENSP00000265277
  • ENSG00000108061
  • ENST00000369452
  • ENSP00000358464

Symbol
  • KIAA0862
  • SOC2
  • SUR8
  • SIAA0862
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
disease perturbation
0.93
transcription factor binding site profile
0.86
histone modification site profile
0.81
microRNA
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.2   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.2   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999989
p_ni:  1e-9
p_wrong:  1e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999984
p_ni:  1.3e-8
p_wrong:  3e-9
Score:  0.987
Data Source:  BioPlex,STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
p_int:  0.999635852
p_ni:  0.000057263
p_wrong:  0.000306885
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.976
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.972
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.968
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.962
Data Source:  STRINGDB
MRAS
Tbio
Family:  Enzyme
Novelty:  0.01544981
Score:  0.962
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.947
Data Source:  STRINGDB
PPP2R2A
Tchem
Family:  Enzyme
Novelty:  0.01723628
Score:  0.939
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
71.1
diet measurement
1
2
2
46.8
neutrophil percentage of leukocytes
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
71.1
diet measurement
2
46.8
neutrophil percentage of leukocytes
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SHOC2, leucine rich repeat scaffold protein
VGNC:12500
466200
Macaque
SHOC2, leucine rich repeat scaffold protein
695572
Mouse
MGI:1927197
56392
Rat
RGD:1308146
309548
Dog
SHOC2, leucine rich repeat scaffold protein
VGNC:46152
477819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SHOC2, leucine rich repeat scaffold protein
Macaque
SHOC2, leucine rich repeat scaffold protein
Mouse
Rat
Dog
SHOC2, leucine rich repeat scaffold protein
Publication Statistics
PubMed Score 90.20
PubMed score by year
PubTator Score 47.90
PubTator score by year
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Related Publications
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PMID
Year
Title