MOK
MAPK/MAK/MRK overlapping kinase
Protein Summary
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
- ENST00000361847
- ENSP00000355304
- ENSG00000080823
- ENST00000522874
- ENSP00000429469
- ENST00000524214
- ENSP00000428942
- RAGE
- RAGE1
- RAGE
- RAGE1
- STK30
- RAGE-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
cell type or tissue | 0.74 | ||
protein domain | 0.73 | ||
tissue sample | 0.64 | ||
tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.37 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 372 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.37 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 372 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0