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Tclin
KCNH4
Potassium voltage-gated channel subfamily H member 4

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264661
  • ENSP00000264661
  • ENSG00000089558
  • ENST00000607371
  • ENSP00000475564

Symbol
  • BEC2
  • ELK1
  • Kv12.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.98
cell line
0.5
cell type or tissue
0.47
transcription factor binding site profile
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.954
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.939
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.935
Data Source:  STRINGDB
DHX58
Tbio
Family:  Enzyme
Novelty:  0.01357081
Score:  0.643
Data Source:  STRINGDB
KCNF1
Tclin
Family:  IC
Novelty:  0.00797195
Score:  0.592
Data Source:  STRINGDB
GHDC
Tbio
Novelty:  0.08423152
Score:  0.573
Data Source:  STRINGDB
KCNS2
Tclin
Family:  IC
Novelty:  0.51090552
Score:  0.567
Data Source:  STRINGDB
KCNK4
Tbio
Family:  IC
Novelty:  0.01173058
Score:  0.562
Data Source:  STRINGDB
KCNQ3
Tclin
Family:  IC
Novelty:  0.00547886
Score:  0.562
Data Source:  STRINGDB
GRIN3A
Tclin
Family:  IC
Novelty:  0.00877072
Score:  0.551
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
77.8
3
2
3
65.7
mean reticulocyte volume
1
1
1
65.6
Thyroid preparation use measurement
1
1
1
61.4
waist-hip ratio
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
77.8
3
65.7
mean reticulocyte volume
1
65.6
Thyroid preparation use measurement
1
61.4
waist-hip ratio
1
57.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 4
VGNC:9342
742588
Macaque
potassium voltage-gated channel subfamily H member 4
100428348
Mouse
MGI:2156184
380728
Rat
RGD:621415
114032
Dog
potassium voltage-gated channel subfamily H member 4
VGNC:42249
607649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 4
Macaque
potassium voltage-gated channel subfamily H member 4
Mouse
Rat
Dog
potassium voltage-gated channel subfamily H member 4
Publication Statistics
PubMed Score 37.65
PubMed score by year
PubTator Score 15.25
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text