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Tchem
ICK
Serine/threonine-protein kinase ICK

Protein Summary
Description
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350082
  • ENSP00000263043
  • ENSG00000112144
  • ENST00000356971
  • ENSP00000349458

Symbol
  • KIAA0936
  • ECO
  • MRK
  • LCK2
  • EJM10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
drug perturbation
0.87
transcription factor binding site profile
0.85
small molecule perturbation
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.68   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.68   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
91.1
smoking initiation
1
1
1
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
91.1
smoking initiation
1
71.8
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Protein-Protein Interactions (66)
1 – 10 of 66
CDK16
Tchem
Family: Kinase
Novelty: 0.02579684
p_int: 0.999953568
p_ni: 5e-9
p_wrong: 0.000046427
Score: 0.42
Data Source: BioPlex,STRINGDB
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
p_int: 0.998287035
p_ni: 0.000010115
p_wrong: 0.00170285
Score: 0.195
Data Source: BioPlex,STRINGDB
CDK14
Tchem
Family: Kinase
Novelty: 0.02074169
p_int: 0.995331539
p_ni: 0.000075454
p_wrong: 0.004593007
Score: 0.401
Data Source: BioPlex,STRINGDB
FAM217B
Tdark
Novelty: 4.03122155
p_int: 0.993492677
p_ni: 0.004526865
p_wrong: 0.001980458
Score: 0.169
Data Source: BioPlex,STRINGDB
DEPDC1
Tbio
Novelty: 0.04255829
p_int: 0.990925844
p_ni: 0.004496295
p_wrong: 0.004577861
Score: 0.175
Data Source: BioPlex,STRINGDB
MSI2
Tbio
Novelty: 0.01716735
p_int: 0.989434814
p_ni: 0.005215805
p_wrong: 0.005349381
Score: 0.2
Data Source: BioPlex,STRINGDB
FCGR3B
Tbio
Novelty: 0.000429
p_int: 0.987816485
p_ni: 0.010481735
p_wrong: 0.00170178
Score: 0.186
Data Source: BioPlex,STRINGDB
SLC35A1
Tbio
Family: Transporter
Novelty: 0.02071929
p_int: 0.983232285
p_ni: 0.014527947
p_wrong: 0.002239768
Score: 0.345
Data Source: BioPlex,STRINGDB
LSM14B
Tdark
Novelty: 0.31832554
p_int: 0.97006277
p_ni: 0.000111681
p_wrong: 0.029825548
Score: 0.187
Data Source: BioPlex,STRINGDB
A4GNT
Tbio
Family: Enzyme
Novelty: 0.08971876
p_int: 0.967140651
p_ni: 0.001110951
p_wrong: 0.031748397
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  122.68

PubMed score by year
PubTator Score  90.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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