You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAPRE3
Microtubule-associated protein RP/EB family member 3

Protein Summary
Description
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233121
  • ENSP00000233121
  • ENSG00000084764
  • ENST00000402218
  • ENSP00000385715
  • ENST00000405074
  • ENSP00000383915
  • ENST00000648289
  • ENSP00000497057

Symbol
  • EB3
  • RP3
  • EBF3
  • EBF3-S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.75
biological process
0.63
PubMedID
0.63
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.33   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.33   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.999999999
p_ni:  1e-9
Score:  0.896
Data Source:  BioPlex,STRINGDB
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.999999996
p_ni:  4e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.99521359
p_ni:  0.004736872
p_wrong:  0.000049538
Score:  0.446
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.914962595
p_ni:  0.004543134
p_wrong:  0.080494271
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.791843749
p_ni:  0.005169351
p_wrong:  0.202986899
Score:  0.154
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.791843749
p_ni:  0.005169351
p_wrong:  0.202986899
Data Source:  BioPlex
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.982
Data Source:  STRINGDB
TUBA1B
Tchem
Novelty:  0.02465964
Score:  0.962
Data Source:  STRINGDB
CKAP5
Tbio
Novelty:  0.00623771
Score:  0.918
Data Source:  STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
Score:  0.89
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
7
7
92
C-reactive protein measurement
2
2
2
78.7
IGF-1 measurement
1
2
2
74.1
neutrophil count
1
1
1
72.9
total cholesterol measurement
1
3
3
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
92
C-reactive protein measurement
2
78.7
IGF-1 measurement
2
74.1
neutrophil count
1
72.9
total cholesterol measurement
3
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
microtubule associated protein RP/EB family member 3
106992881
Mouse
MGI:2140967
100732
Rat
RGD:1359297
298848
Dog
microtubule associated protein RP/EB family member 3
VGNC:43011
475694
Horse
microtubule associated protein RP/EB family member 3
100629914
Species
Name
OMA
EggNOG
Inparanoid
Macaque
microtubule associated protein RP/EB family member 3
Mouse
Rat
Dog
microtubule associated protein RP/EB family member 3
Horse
microtubule associated protein RP/EB family member 3
Publication Statistics
PubMed Score 224.33
PubMed score by year
PubTator Score 70.91
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title