MAPRE3
Microtubule-associated protein RP/EB family member 3
Protein Summary
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
- ENST00000233121
- ENSP00000233121
- ENSG00000084764
- ENST00000402218
- ENSP00000385715
- ENST00000405074
- ENSP00000383915
- ENST00000648289
- ENSP00000497057
- EB3
- RP3
- EBF3
- EBF3-S
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
histone modification site profile | 0.75 | ||
biological process | 0.63 | ||
PubMedID | 0.63 | ||
tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 224.33 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 234 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 224.33 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 234 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (159)
GAS2L1
Novelty: 0.17484834
p_int: 0.999999999
p_ni: 1e-9
Score: 0.896
Data Source: BioPlex,STRINGDB
MAPRE1
Novelty: 0.01267772
p_int: 0.999999996
p_ni: 4e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
PDE4DIP
Novelty: 0.03414104
p_int: 0.99521359
p_ni: 0.004736872
p_wrong: 0.000049538
Score: 0.446
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.914962595
p_ni: 0.004543134
p_wrong: 0.080494271
Data Source: BioPlex
HAX1
Novelty: 0.00749205
p_int: 0.791843749
p_ni: 0.005169351
p_wrong: 0.202986899
Score: 0.154
Data Source: BioPlex,STRINGDB
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.791843749
p_ni: 0.005169351
p_wrong: 0.202986899
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (9)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 7 | 7 | 92 | |||||
C-reactive protein measurement | 2 | 2 | 2 | 78.7 | |||||
IGF-1 measurement | 1 | 2 | 2 | 74.1 | |||||
neutrophil count | 1 | 1 | 1 | 72.9 | |||||
total cholesterol measurement | 1 | 3 | 3 | 72.1 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 7 | 92 | |||||
C-reactive protein measurement | 2 | 78.7 | |||||
IGF-1 measurement | 2 | 74.1 | |||||
neutrophil count | 1 | 72.9 | |||||
total cholesterol measurement | 3 | 72.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | microtubule associated protein RP/EB family member 3 | 106992881 | ||||||
Mouse | MGI:2140967 | 100732 | ||||||
Rat | RGD:1359297 | 298848 | ||||||
Dog | microtubule associated protein RP/EB family member 3 | VGNC:43011 | 475694 | |||||
Horse | microtubule associated protein RP/EB family member 3 | 100629914 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | microtubule associated protein RP/EB family member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | microtubule associated protein RP/EB family member 3 | |||||
Horse | microtubule associated protein RP/EB family member 3 | |||||
Publication Statistics
PubMed Score 224.33
PubMed score by year
PubTator Score 70.91
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (16)
Items per page:
0 of 0
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