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Tbio
WASF3
Wiskott-Aldrich syndrome protein family member 3

Protein Summary
Description
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335327
  • ENSP00000335055
  • ENSG00000132970
  • ENST00000361042
  • ENSP00000354325

Symbol
  • KIAA0900
  • SCAR3
  • WAVE3
  • SCAR3
  • WAVE3
  • Brush-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
tissue sample
0.76
transcription factor
0.67
kinase perturbation
0.66
microRNA
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.37   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.37   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAS protein family member 3
VGNC:5133
452502
Macaque
WAS protein family member 3
709849
Mouse
MGI:2658986
245880
Dog
WAS protein family member 3
VGNC:48335
477331
Horse
WAS protein family member 3
VGNC:24966
100050895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAS protein family member 3
Macaque
WAS protein family member 3
Mouse
Dog
WAS protein family member 3
Horse
WAS protein family member 3
Pathways (14)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
ABI2
Tbio
Novelty: 0.02324355
p_int: 1
Score: 0.989
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999926949
p_ni: 0.000072847
p_wrong: 2.04e-7
Score: 0.708
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999871155
p_ni: 0.000122469
p_wrong: 0.000006376
Score: 0.671
Data Source: BioPlex,STRINGDB
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.999782665
p_ni: 0.000217323
p_wrong: 1.1e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.999606081
p_ni: 0.00039392
Score: 0.997
Data Source: BioPlex,STRINGDB
GTF2IRD1
Tbio
Family: TF
Novelty: 0.01858027
p_int: 0.998761347
p_ni: 0.001238628
p_wrong: 2.5e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.998204449
p_ni: 0.001739202
p_wrong: 0.000056349
Score: 0.998
Data Source: BioPlex,STRINGDB
CMTR1
Tbio
Family: Enzyme
Novelty: 0.09259694
p_int: 0.990119422
p_ni: 0.009880578
Score: 0.205
Data Source: BioPlex,STRINGDB
CYFIP2
Tbio
Novelty: 0.01910939
p_int: 0.98970798
p_ni: 0.01029202
Score: 0.993
Data Source: BioPlex,STRINGDB
HOXB9
Tbio
Family: TF
Novelty: 0.01591519
p_int: 0.973373147
p_ni: 0.026183857
p_wrong: 0.000442996
Score: 0.185
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  54.37

PubMed score by year
PubTator Score  211.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer