Tbio SHANK2 SH3 and multiple ankyrin repeat domains protein 2

Protein Summary

Description

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q9UPX8
• C0SPG8
• C0SPG9
• Q3Y8G9
• Q52LK2
• Q9UKP1
• Shank2

Gene Name

• SHANK2

Ensembl ID

• ENST00000409530
• ENSP00000387324
• ENSG00000162105
• ENST00000601538
• ENSP00000469689

Symbol

• CORTBP1
• KIAA1022
• PROSAP1
• SHANK
• AUTS17
• CORTBP1
• CTTNBP1
• ProSAP1
• SPANK-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.85
protein domain	0.85
cellular component	0.75
disease perturbation	0.74
transcription factor	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.44   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.44   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0