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Tbio
SATB2
DNA-binding protein SATB2

Protein Classes
Protein Summary
Description
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. This gene encodes a DNA binding protein that speci ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260926
  • ENSP00000260926
  • ENSG00000119042
  • ENST00000417098
  • ENSP00000401112
  • ENST00000428695
  • ENSP00000388581
  • ENST00000457245
  • ENSP00000405420
  • ENST00000614512
  • ENSP00000483287

Symbol
  • KIAA1034
  • GLSS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
microRNA
0.81
PubMedID
0.78
kinase perturbation
0.76
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.29   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.29   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
97.8
age at menarche
1
1
1
73
worry measurement
1
1
1
64.2
4
2
0
1.1
64.2
cerebrospinal fluid biomarker measurement
1
1
0
20
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
97.8
age at menarche
1
73
worry measurement
1
64.2
0
1.1
64.2
cerebrospinal fluid biomarker measurement
0
20
31.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RNA Polymerase II Transcription
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
SATB1
Tbio
Family: TF
Novelty: 0.00434577
p_int: 0.999999989
p_ni: 1.1e-8
p_wrong: 1e-9
Data Source: BioPlex
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.999998305
p_ni: 0.000001695
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.999993552
p_ni: 0.000006448
Data Source: BioPlex
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.999989946
p_ni: 0.000010054
Data Source: BioPlex
MORF4L2
Tbio
Novelty: 0.09897629
p_int: 0.999987635
p_ni: 0.000012356
p_wrong: 9e-9
Data Source: BioPlex
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.999979095
p_ni: 0.000020905
Data Source: BioPlex
TRIM47
Tbio
Novelty: 0.01631355
p_int: 0.999977032
p_ni: 0.000002934
p_wrong: 0.000020035
Data Source: BioPlex
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.999968789
p_ni: 0.000031211
Data Source: BioPlex
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.999853185
p_ni: 0.000146809
p_wrong: 6e-9
Data Source: BioPlex
RFPL4B
Tdark
Novelty: 2.42779597
p_int: 0.999146041
p_ni: 0.000853934
p_wrong: 2.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  287.29

PubMed score by year
PubTator Score  119.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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