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Tbio
AGTPBP1
Cytosolic carboxypeptidase 1

Protein Summary
Description
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357081
  • ENSP00000349592
  • ENSG00000135049
  • ENST00000376083
  • ENSP00000365251
  • ENST00000628899
  • ENSP00000487074

Symbol
  • CCP1
  • KIAA1035
  • NNA1
  • CCP1
  • NNA1
  • CONDCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.88
kinase perturbation
0.88
transcription factor binding site profile
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.998251901
p_ni:  0.001452291
p_wrong:  0.000295808
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.995499807
p_ni:  0.003851463
p_wrong:  0.000648729
Data Source:  BioPlex
TMOD1
Tbio
Novelty:  0.01142927
p_int:  0.989437573
p_ni:  0.0003112
p_wrong:  0.010251227
Score:  0.527
Data Source:  BioPlex,STRINGDB
TTLL4
Tbio
Family:  Enzyme
Novelty:  0.14127442
p_int:  0.982047559
p_ni:  0.002942959
p_wrong:  0.015009482
Score:  0.787
Data Source:  BioPlex,STRINGDB
NAA35
Tbio
Family:  Enzyme
Novelty:  0.04980045
Score:  0.761
Data Source:  STRINGDB
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
Score:  0.722
Data Source:  STRINGDB
AEBP1
Tbio
Novelty:  0.01833511
Score:  0.691
Data Source:  STRINGDB
TTL
Tchem
Family:  Enzyme
Novelty:  0.03494724
Score:  0.685
Data Source:  STRINGDB
CPXM2
Tbio
Family:  Enzyme
Novelty:  0.09967229
Score:  0.683
Data Source:  STRINGDB
ASB5
Tdark
Novelty:  0.33891683
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
13.4
biological sex
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
13.4
biological sex
1
2.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein 1
VGNC:4604
464558
Macaque
ATP/GTP binding protein 1
709949
Mouse
MGI:2159437
67269
Rat
RGD:1306307
290986
Dog
ATP/GTP binding protein 1
VGNC:37719
484146
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein 1
Macaque
ATP/GTP binding protein 1
Mouse
Rat
Dog
ATP/GTP binding protein 1
Publication Statistics
PubMed Score 61.59
PubMed score by year
PubTator Score 11.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title