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Tbio
TRAK1
Trafficking kinesin-binding protein 1

Protein Summary
Description
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327628
  • ENSP00000328998
  • ENSG00000182606
  • ENST00000341421
  • ENSP00000340702
  • ENST00000449246
  • ENSP00000410717

Symbol
  • KIAA1042
  • OIP106
  • MILT1
  • EIEE68
  • OIP106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.96
kinase perturbation
0.76
microRNA
0.69
cell line
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0