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Tdark
TBC1D2B
TBC1 domain family member 2B

Protein Summary
Description
May act as a GTPase-activating protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300584
  • ENSP00000300584
  • ENSG00000167202
  • ENST00000409931
  • ENSP00000387165

Symbol
  • KIAA1055
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.81
cell line
0.6
tissue sample
0.59
disease perturbation
0.56
microRNA
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
3
3
80.5
hematocrit
1
1
1
10.2
hemoglobin measurement
1
1
1
9.8
cigarettes per day measurement
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
80.5
hematocrit
1
10.2
hemoglobin measurement
1
9.8
cigarettes per day measurement
1
4.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 2B
VGNC:3523
453563
Macaque
TBC1 domain family member 2B
716076
Mouse
MGI:1914266
67016
Rat
RGD:1307436
315880
Dog
TBC1 domain family member 2B
VGNC:47145
488776
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 2B
Macaque
TBC1 domain family member 2B
Mouse
Rat
Dog
TBC1 domain family member 2B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
PTCD3
Tbio
Novelty:  0.12368434
p_int:  0.999999258
p_ni:  7.41e-7
p_wrong:  1e-9
Data Source:  BioPlex
CEP120
Tbio
Novelty:  0.07215656
p_int:  0.999996668
p_ni:  0.000002783
p_wrong:  5.48e-7
Data Source:  BioPlex
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.99997462
p_ni:  0.00002538
Score:  0.206
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.999942066
p_ni:  0.000057934
Data Source:  BioPlex
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999763911
p_ni:  0.000236089
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.999719977
p_ni:  0.000280023
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999214508
p_ni:  0.000785492
Data Source:  BioPlex
SNX16
Tbio
Novelty:  0.13364491
p_int:  0.998266303
p_ni:  0.001733697
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.995515944
p_ni:  0.004484056
Score:  0.152
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.993265265
p_ni:  0.006734735
Data Source:  BioPlex
Publication Statistics
PubMed Score  1.56

PubMed score by year
PubTator Score  0.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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