Tbio USP24 Ubiquitin carboxyl-terminal hydrolase 24

Protein Summary

Description

Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UPU5
• Q6ZSY2
• Q8N2Y4
• Q9NXD1

Gene Name

• USP24

Ensembl ID

• ENST00000294383
• ENSP00000294383
• ENSG00000162402

Symbol

• KIAA1057

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
protein domain	0.92
transcription factor perturbation	0.84
microRNA	0.82
interacting protein	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.57   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.57   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0