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Tbio
USP22
Ubiquitin carboxyl-terminal hydrolase 22

Protein Summary
Description
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261497
  • ENSP00000261497
  • ENSG00000124422
  • ENST00000537526
  • ENSP00000440950

Symbol
  • KIAA1063
  • USP3L
  • USP3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.96
kinase perturbation
0.95
transcription factor binding site profile
0.86
biological process
0.84


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.79   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.79   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 22
VGNC:9770
454511
Macaque
ubiquitin specific peptidase 22
712098
Mouse
MGI:2144157
216825
Rat
RGD:1310354
303201
Dog
ubiquitin specific peptidase 22
609588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 22
Macaque
ubiquitin specific peptidase 22
Mouse
Rat
Dog
ubiquitin specific peptidase 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPT9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (131)
1 – 10 of 131
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.999999566
p_ni:  4.34e-7
Score:  0.627
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999999543
p_ni:  3.66e-7
p_wrong:  9.1e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999971211
p_ni:  0.000028787
p_wrong:  1e-9
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.999757986
p_ni:  0.000242014
Data Source:  BioPlex
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.999529037
p_ni:  0.000470961
p_wrong:  2e-9
Data Source:  BioPlex
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
p_int:  0.996011016
p_ni:  0.003988784
p_wrong:  2e-7
Data Source:  BioPlex
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.994967138
p_ni:  0.005032785
p_wrong:  7.8e-8
Data Source:  BioPlex
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.993986575
p_ni:  0.006012958
p_wrong:  4.66e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.987616148
p_ni:  0.012370991
p_wrong:  0.000012861
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.973421104
p_ni:  0.026578889
p_wrong:  7e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  113.79

PubMed score by year
PubTator Score  57.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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