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Tbio
MAPK8IP3
C-Jun-amino-terminal kinase-interacting protein 3

Protein Summary
Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250894
  • ENSP00000250894
  • ENSG00000138834

Symbol
  • JIP3
  • KIAA1066
  • syd
  • JIP3
  • SYD2
  • JIP-3
  • JSAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
biological process
0.77
cellular component
0.73
histone modification site profile
0.69
hub protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.05   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.05   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
p_int:  0.999999556
p_ni:  2.1e-7
p_wrong:  2.33e-7
Score:  0.945
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999871027
p_ni:  0.000128973
Score:  0.214
Data Source:  BioPlex,STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
p_int:  0.999753312
p_ni:  0.000246688
Score:  0.944
Data Source:  BioPlex,STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.998462761
p_ni:  0.001537239
Score:  0.559
Data Source:  BioPlex,STRINGDB
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.998213611
p_ni:  0.001786389
Score:  0.305
Data Source:  BioPlex,STRINGDB
SMCO1
Tdark
Novelty:  0.56580218
p_int:  0.997665079
p_ni:  0.002334921
Score:  0.862
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.986172691
p_ni:  0.013827291
p_wrong:  1.8e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.930916006
p_ni:  0.069069362
p_wrong:  0.000014632
Score:  0.597
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.930472474
p_ni:  0.069523981
p_wrong:  0.000003545
Score:  0.294
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.917839317
p_ni:  0.082160683
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
9
9
99
appendicular lean mass
3
1
3
75.7
sex hormone-binding globulin measurement
2
1
2
56.4
blood metabolite measurement
1
1
1
49.5
maculopapular eruption
1
1
0
14
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
9
99
appendicular lean mass
3
75.7
sex hormone-binding globulin measurement
2
56.4
blood metabolite measurement
1
49.5
maculopapular eruption
0
14
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 3
VGNC:8988
453825
Macaque
mitogen-activated protein kinase 8 interacting protein 3
702388
Mouse
MGI:1353598
30957
Rat
RGD:1563691
302983
Dog
mitogen-activated protein kinase 8 interacting protein 3
VGNC:43003
100684766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 3
Macaque
mitogen-activated protein kinase 8 interacting protein 3
Mouse
Rat
Dog
mitogen-activated protein kinase 8 interacting protein 3
Publication Statistics
PubMed Score 98.05
PubMed score by year
PubTator Score 48.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title