Protein Summary
Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
- ENST00000372586
- ENSP00000361667
- ENSG00000175283
- KIAA1094
- TMEM15
- DK
- DK1
- CDG1M
- SEC59
- TMEM15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
histone modification site profile | 0.9 | ||
virus perturbation | 0.9 | ||
tissue sample | 0.65 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.38 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 70 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.38 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 70 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (14)
Reactome (10)
KEGG (2)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective DOLK causes DOLK-CDG (CDG-1m) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosylation precursor biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective DOLK causes DOLK-CDG (CDG-1m) | ||||
Disease | ||||
Diseases associated with glycosylation precursor biosynthesis | ||||
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (92)
1 – 10 of 92
OPALIN
Novelty: 0.06813417
p_int: 0.999536341
p_ni: 0.000463026
p_wrong: 6.33e-7
Data Source: BioPlex
KCNA6
Family: IC
p_int: 0.999343011
p_ni: 0.000528213
p_wrong: 0.000128776
Score: 0.234
Data Source: BioPlex,STRINGDB
TNFRSF1A
Novelty: 0.00048442
p_int: 0.998829042
p_ni: 0.001084126
p_wrong: 0.000086833
Data Source: BioPlex
CD274
Novelty: 0.00020953
p_int: 0.996846914
p_ni: 0.003124411
p_wrong: 0.000028675
Data Source: BioPlex
FPR2
Family: GPCR
Novelty: 0.00286277
p_int: 0.996482621
p_ni: 0.003154789
p_wrong: 0.000362589
Data Source: BioPlex
ERGIC3
Novelty: 0.15783642
p_int: 0.995591599
p_ni: 0.004345223
p_wrong: 0.000063178
Score: 0.154
Data Source: BioPlex,STRINGDB
KCNA5
Family: IC
Novelty: 0.00228979
p_int: 0.991048698
p_ni: 0.000451902
p_wrong: 0.0084994
Data Source: BioPlex
TPRA1
Family: GPCR
Novelty: 0.39628306
p_int: 0.966789374
p_ni: 0.025962657
p_wrong: 0.00724797
Score: 0.162
Data Source: BioPlex,STRINGDB
CACNG1
Family: IC
Novelty: 0.174255
p_int: 0.96317979
p_ni: 0.027472301
p_wrong: 0.009347909
Data Source: BioPlex
APLNR
Family: GPCR
Novelty: 0.001441
p_int: 0.96288607
p_ni: 0.035239602
p_wrong: 0.001874328
Data Source: BioPlex
Publication Statistics
PubMed Score 85.38
PubMed score by year
PubTator Score 7.64
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAV
1-70
FQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNT
70-140
CVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIK
140-210
RSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIR
210-280
RNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIP
280-350
GIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIW
350-420
LIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALI
420-490
LIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
490-538
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
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