You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PDZRN3
E3 ubiquitin-protein ligase PDZRN3

Protein Summary
Description
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263666
  • ENSP00000263666
  • ENSG00000121440
  • ENST00000308537
  • ENSP00000308831

Symbol
  • KIAA1095
  • LNX3
  • SEMCAP3
  • LNX3
  • SEMCAP3
  • SEMACAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.88
transcription factor perturbation
0.8
tissue sample
0.66
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
2
1
2
83.3
electrocardiography
1
1
7
42.1
PR interval
1
1
0
1.1
27.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
2
83.3
electrocardiography
7
42.1
PR interval
0
1.1
27.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PDZ domain containing ring finger 3
709901
Mouse
MGI:1933157
55983
Rat
RGD:1305250
312607
Horse
PDZ domain containing ring finger 3
VGNC:21294
100061813
Cow
PDZ domain containing ring finger 3
VGNC:32731
509083
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PDZ domain containing ring finger 3
Mouse
Rat
Horse
PDZ domain containing ring finger 3
Cow
PDZ domain containing ring finger 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UPQ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (73)
1 – 10 of 73
SDHA
Tbio
Family: Enzyme
Novelty: 0.00223171
p_int: 0.999999493
p_ni: 5.05e-7
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.999995217
p_ni: 0.000004778
p_wrong: 5e-9
Score: 0.162
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999975137
p_ni: 0.000024863
Score: 0.158
Data Source: BioPlex,STRINGDB
FAM13C
Tdark
Novelty: 0.63294359
p_int: 0.999963172
p_ni: 0.000036828
Score: 0.558
Data Source: BioPlex,STRINGDB
RBM12B
Tdark
Novelty: 0.96079205
p_int: 0.999946044
p_ni: 0.000053954
p_wrong: 2e-9
Data Source: BioPlex
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.996233942
p_ni: 0.003374493
p_wrong: 0.000391566
Data Source: BioPlex
OIP5
Tbio
Novelty: 0.02546471
p_int: 0.995303148
p_ni: 0.004696664
p_wrong: 1.88e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
MUSK
Tchem
Family: Kinase
Novelty: 0.00151518
Score: 0.844
Data Source: STRINGDB
ATXN7L3
Tbio
Novelty: 0.1572083
Score: 0.707
Data Source: STRINGDB
USP12
Tbio
Family: Enzyme
Novelty: 0.0460009
Score: 0.661
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.99

PubMed score by year
PubTator Score  16.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: