You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Protein Summary
Description
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304032
  • ENSP00000307634
  • ENSG00000157985
  • ENST00000336665
  • ENSP00000338378
  • ENST00000409457
  • ENSP00000387174

Symbol
  • CENTG2
  • KIAA1099
  • GGAP1
  • AGAP-1
  • CENTG2
  • cnt-g2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
disease perturbation
0.93
protein domain
0.92
virus perturbation
0.76
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (31)
1 – 10 of 31
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999999104
p_ni:  8.96e-7
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999998336
p_ni:  0.000001658
p_wrong:  7e-9
Data Source:  BioPlex
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.999446195
p_ni:  0.0005538
p_wrong:  4e-9
Score:  0.218
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999374709
p_ni:  0.000625291
Score:  0.158
Data Source:  BioPlex,STRINGDB
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.998869253
p_ni:  0.000903203
p_wrong:  0.000227544
Score:  0.188
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.998829228
p_ni:  0.001008276
p_wrong:  0.000162496
Score:  0.214
Data Source:  BioPlex,STRINGDB
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.998599306
p_ni:  0.001213638
p_wrong:  0.000187055
Score:  0.159
Data Source:  BioPlex,STRINGDB
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.988265741
p_ni:  0.011703633
p_wrong:  0.000030626
Score:  0.17
Data Source:  BioPlex,STRINGDB
PCDHA10
Tdark
Novelty:  0.73702568
p_int:  0.95884612
p_ni:  0.04115194
p_wrong:  0.00000194
Score:  0.321
Data Source:  BioPlex,STRINGDB
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.831521027
p_ni:  0.001011652
p_wrong:  0.167467321
Score:  0.21
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
6
7
1.1
82.1
mathematical ability
2
2
3
63.9
Hemifacial microsomia
1
1
0
1.4
56.8
body mass index
1
2
2
50.5
hair colour measurement
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
1.1
82.1
mathematical ability
3
63.9
Hemifacial microsomia
0
1.4
56.8
body mass index
2
50.5
hair colour measurement
1
37.6
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
VGNC:10551
744080
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
693652
Mouse
MGI:2653690
347722
Rat
RGD:1309244
316611
Chicken
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
CGNC:52113
424024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Mouse
Rat
Chicken
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Publication Statistics
PubMed Score 18.53
PubMed score by year
PubTator Score 9.00
PubTator score by year