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Tbio
LIMCH1
LIM and calponin homology domains-containing protein 1

Protein Summary
Description
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313860
  • ENSP00000316891
  • ENSG00000064042
  • ENST00000381753
  • ENSP00000371172
  • ENST00000396595
  • ENSP00000379840
  • ENST00000508501
  • ENSP00000424825
  • ENST00000511496
  • ENSP00000421242
  • ENST00000512820
  • ENSP00000424437
  • ENST00000512946
  • ENSP00000424645
  • ENST00000513024
  • ENSP00000425222

Symbol
  • KIAA1102
  • LMO7B
  • LIMCH1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.91
PubMedID
0.9
kinase perturbation
0.88
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
14.7
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (60)
1 – 10 of 60
OTUD6B
Tbio
Novelty: 0.14800249
p_int: 0.94277181
p_ni: 0.05722819
Score: 0.485
Data Source: BioPlex,STRINGDB
KLHL15
Tbio
Novelty: 0.54712519
p_int: 0.941813875
p_ni: 0.058186125
Score: 0.187
Data Source: BioPlex,STRINGDB
ANKRD50
Tdark
Novelty: 0.7929169
Score: 0.648
Data Source: STRINGDB
C8orf59
Tdark
Novelty: 5.32637076
Score: 0.618
Data Source: STRINGDB
ARL9
Tdark
Family: Enzyme
Novelty: 0.87210932
Score: 0.599
Data Source: STRINGDB
TMEM33
Tbio
Novelty: 0.15083104
Score: 0.591
Data Source: STRINGDB
RHPN2
Tbio
Novelty: 0.04808006
Score: 0.586
Data Source: STRINGDB
FHL2
Tbio
Novelty: 0.00501273
Score: 0.583
Data Source: STRINGDB
R3HCC1
Tdark
Novelty: 1.93729169
Score: 0.567
Data Source: STRINGDB
EPS8L2
Tbio
Family: Enzyme
Novelty: 0.22588143
Score: 0.563
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.18

PubMed score by year
PubTator Score  2.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer