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Tbio
LIMCH1
LIM and calponin homology domains-containing protein 1

Protein Summary
Description
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313860
  • ENSP00000316891
  • ENSG00000064042
  • ENST00000381753
  • ENSP00000371172
  • ENST00000396595
  • ENSP00000379840
  • ENST00000508501
  • ENSP00000424825
  • ENST00000511496
  • ENSP00000421242
  • ENST00000512820
  • ENSP00000424437
  • ENST00000512946
  • ENSP00000424645
  • ENST00000513024
  • ENSP00000425222

Symbol
  • KIAA1102
  • LMO7B
  • LIMCH1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.91
PubMedID
0.9
kinase perturbation
0.88
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0