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Tbio
IQSEC3
IQ motif and SEC7 domain-containing protein 3

Protein Summary
Description
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382841
  • ENSP00000372292
  • ENSG00000120645
  • ENST00000538872
  • ENSP00000437554
  • ENST00000571363
  • ENSP00000461043
  • ENSG00000262607

Symbol
  • KIAA1110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
phenotype
0.64
trait
0.61
cell line
0.59
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MON2
Tbio
Novelty:  0.02807677
Score:  0.757
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.689
Data Source:  STRINGDB
RBFOX3
Tbio
Novelty:  0.00038317
Score:  0.678
Data Source:  STRINGDB
RBM43
Tdark
Novelty:  0.33457489
Score:  0.673
Data Source:  STRINGDB
MDGA2
Tbio
Novelty:  0.07784646
Score:  0.658
Data Source:  STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.651
Data Source:  STRINGDB
ERC1
Tbio
Novelty:  0.01251
Score:  0.65
Data Source:  STRINGDB
SLITRK3
Tbio
Novelty:  0.17365933
Score:  0.649
Data Source:  STRINGDB
RBSN
Tbio
Novelty:  0.0046123
Score:  0.645
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
6
8
9.4
96.7
blood metabolite measurement
2
3
3
91.9
creatinine measurement
5
4
5
80.5
serum metabolite measurement
1
1
1
55.2
3-hydroxyisobutyrate measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
9.4
96.7
blood metabolite measurement
3
91.9
creatinine measurement
5
80.5
serum metabolite measurement
1
55.2
3-hydroxyisobutyrate measurement
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif and Sec7 domain 3
VGNC:13154
749108
Mouse
MGI:2677208
243621
Rat
RGD:1593191
404781
Dog
IQ motif and Sec7 domain 3
VGNC:42085
486747
Pig
IQ motif and Sec7 domain 3
100515547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif and Sec7 domain 3
Mouse
Rat
Dog
IQ motif and Sec7 domain 3
Pig
IQ motif and Sec7 domain 3
Publication Statistics
PubMed Score 5.84
PubMed score by year
PubTator Score 2.59
PubTator score by year
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Related Publications
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PMID
Year
Title