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Tbio
MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Protein Summary
Description
Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:1526568 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289893
  • ENSP00000289893
  • ENSG00000127603
  • ENST00000361689
  • ENSP00000354573
  • ENST00000372915
  • ENSP00000362006

Symbol
  • ABP620
  • ACF7
  • KIAA0465
  • KIAA1251
  • ACF7
  • LIS9
  • MACF
  • OFC4
  • ABP620
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.99
ligand (protein) perturbation
0.99
biological process
0.86
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.22   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.22   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
AMMECR1L
Tdark
Novelty:  0.60058793
p_int:  0.99990202
p_ni:  0.00009798
Score:  0.229
Data Source:  BioPlex,STRINGDB
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.995075311
p_ni:  0.004924689
Score:  0.926
Data Source:  BioPlex,STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
p_int:  0.958664885
p_ni:  0.041335115
Score:  0.177
Data Source:  BioPlex,STRINGDB
ALX3
Tbio
Family:  TF
Novelty:  0.02711914
p_int:  0.939510443
p_ni:  0.060489557
Score:  0.158
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.937536468
p_ni:  0.062463532
Score:  0.274
Data Source:  BioPlex,STRINGDB
CDKL5
Tchem
Family:  Kinase
Novelty:  0.00444062
p_int:  0.922073245
p_ni:  0.077926755
Score:  0.243
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.899209631
p_ni:  0.100790369
Data Source:  BioPlex
SYNE3
Tbio
Novelty:  0.06515065
Score:  0.939
Data Source:  STRINGDB
MAPRE3
Tbio
Novelty:  0.00454315
Score:  0.851
Data Source:  STRINGDB
MAPRE2
Tbio
Novelty:  0.00692773
Score:  0.801
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
11
18
99.2
apolipoprotein A 1 measurement
2
5
5
98.1
11
7
3
1.1
97.8
C-reactive protein measurement
4
5
6
96.2
mean corpuscular hemoglobin concentration
2
2
2
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
99.2
apolipoprotein A 1 measurement
5
98.1
3
1.1
97.8
C-reactive protein measurement
6
96.2
mean corpuscular hemoglobin concentration
2
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108559
11426
Dog
microtubule-actin crosslinking factor 1
VGNC:54215
475321
Horse
microtubule-actin crosslinking factor 1
100068727
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
microtubule-actin crosslinking factor 1
Horse
microtubule-actin crosslinking factor 1
Publication Statistics
PubMed Score 102.22
PubMed score by year
PubTator Score 45.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title