Tbio MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Protein Summary

Description

Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q9UPN3
• B1ALC5
• E9PJT0
• O75053
• Q5VW20
• Q8WXY1
• Q8WXY2
• Q96PK2
• Q9H540
• Q9UKP0
• Q9ULG9

Gene Name

• MACF1

Ensembl ID

• ENST00000289893
• ENSP00000289893
• ENSG00000127603
• ENST00000361689
• ENSP00000354573
• ENST00000372915
• ENSP00000362006

Symbol

• ABP620
• ACF7
• KIAA0465
• KIAA1251
• ACF7
• LIS9
• MACF
• OFC4
• ABP620

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
interacting protein	0.99
ligand (protein) perturbation	0.99
biological process	0.86
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Intermediate Filament / Intermediate Filament Binding Protein / Microtubule-actin Cross-linking Factor 1, Isoforms 1/2/3/5

DTO Classes

Protein / Cellular Structure / Intermediate Filament / Intermediate Filament Binding Protein / Microtubule-actin Cross-linking Factor 1, Isoforms 1/2/3/5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.24   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.24   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0