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Tbio
LHX6
LIM/homeobox protein Lhx6

Protein Summary
Description
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340587
  • ENSP00000340137
  • ENSG00000106852
  • ENST00000373754
  • ENSP00000362859
  • ENST00000373755
  • ENSP00000362860
  • ENST00000394319
  • ENSP00000377854
  • ENST00000541397
  • ENSP00000441464
  • ENST00000559895
  • ENSP00000475927

Symbol
  • LHX6.1
  • LHX6.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
tissue sample
0.76
small molecule perturbation
0.73
PubMedID
0.7
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.73   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.73   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 6
VGNC:13909
735560
Macaque
LIM homeobox 6
698587
Mouse
MGI:1306803
16874
Rat
RGD:1306174
311901
Dog
LIM homeobox 6
VGNC:42667
491354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 6
Macaque
LIM homeobox 6
Mouse
Rat
Dog
LIM homeobox 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPM6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
ATG2B
Tbio
Novelty: 0.04963717
p_int: 0.999999905
p_ni: 9.5e-8
Score: 0.538
Data Source: BioPlex,STRINGDB
LDB1
Tbio
Novelty: 0.01110112
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.956
Data Source: BioPlex,STRINGDB
SSBP3
Tbio
Novelty: 0.01955714
p_int: 0.999999702
p_ni: 2.97e-7
p_wrong: 1e-9
Score: 0.741
Data Source: BioPlex,STRINGDB
SSBP4
Tdark
Novelty: 0.27365687
p_int: 0.999999623
p_ni: 3.74e-7
p_wrong: 3e-9
Score: 0.786
Data Source: BioPlex,STRINGDB
NUDT22
Tbio
Novelty: 0.44528464
p_int: 0.999998984
p_ni: 2.15e-7
p_wrong: 8e-7
Score: 0.26
Data Source: BioPlex,STRINGDB
SSBP2
Tbio
Novelty: 0.06546999
p_int: 0.999997259
p_ni: 0.000002741
Score: 0.759
Data Source: BioPlex,STRINGDB
WDR45
Tbio
Novelty: 0.0148072
p_int: 0.999994738
p_ni: 0.000005262
Score: 0.735
Data Source: BioPlex,STRINGDB
ZNF507
Tdark
Family: TF
Novelty: 1.0899905
p_int: 0.999924944
p_ni: 0.000075056
Score: 0.173
Data Source: BioPlex,STRINGDB
RNF187
Tbio
Family: Enzyme
Novelty: 0.13506464
p_int: 0.999457286
p_ni: 0.00054187
p_wrong: 8.43e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.99893605
p_ni: 0.001063837
p_wrong: 1.14e-7
Score: 0.474
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.73

PubMed score by year
PubTator Score  25.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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