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Tchem
SRPK3
SRSF protein kinase 3

Protein Summary
Description
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370101
  • ENSP00000359119
  • ENSG00000184343
  • ENST00000370104
  • ENSP00000359122
  • ENST00000393786
  • ENSP00000377376

Symbol
  • MSSK1
  • STK23
  • MSSK1
  • STK23
  • MSSK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
molecular function
0.91
gene perturbation
0.58
protein domain
0.58
cell type or tissue
0.5


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRSF protein kinase 3
VGNC:1194
100611755
Macaque
SRSF protein kinase 3
100429812
Mouse
MGI:1891338
56504
Rat
RGD:727856
293854
Dog
SRSF protein kinase 3
VGNC:46812
612525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRSF protein kinase 3
Macaque
SRSF protein kinase 3
Mouse
Rat
Dog
SRSF protein kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPE1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
SRSF6
Tbio
Novelty: 0.00396762
Score: 0.784
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.748
Data Source: STRINGDB
SLC2A13
Tbio
Family: Transporter
Novelty: 0.04641021
Score: 0.743
Data Source: STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.729
Data Source: STRINGDB
GPRIN1
Tbio
Novelty: 0.14698407
Score: 0.724
Data Source: STRINGDB
SRSF4
Tbio
Novelty: 0.04065547
Score: 0.698
Data Source: STRINGDB
ICA1L
Tdark
Novelty: 0.69333512
Score: 0.692
Data Source: STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
Score: 0.659
Data Source: STRINGDB
PRPF4B
Tchem
Family: Kinase
Novelty: 0.05912788
Score: 0.621
Data Source: STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
Score: 0.606
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.59

PubMed score by year
PubTator Score  2.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer