You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SRPK3
SRSF protein kinase 3

Protein Summary
Description
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370101
  • ENSP00000359119
  • ENSG00000184343
  • ENST00000370104
  • ENSP00000359122
  • ENST00000393786
  • ENSP00000377376

Symbol
  • MSSK1
  • STK23
  • MSSK1
  • STK23
  • MSSK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
molecular function
0.91
gene perturbation
0.58
protein domain
0.58
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
SRSF6
Tbio
Novelty: 0.00396762
Score: 0.784
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.748
Data Source: STRINGDB
SLC2A13
Tbio
Family: Transporter
Novelty: 0.04641021
Score: 0.743
Data Source: STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
Score: 0.729
Data Source: STRINGDB
GPRIN1
Tbio
Novelty: 0.14698407
Score: 0.724
Data Source: STRINGDB
SRSF4
Tbio
Novelty: 0.04065547
Score: 0.698
Data Source: STRINGDB
ICA1L
Tdark
Novelty: 0.69333512
Score: 0.692
Data Source: STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
Score: 0.659
Data Source: STRINGDB
PRPF4B
Tchem
Family: Kinase
Novelty: 0.05912788
Score: 0.621
Data Source: STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
Score: 0.606
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.59

PubMed score by year
PubTator Score  2.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer