Tchem GPR34 Probable G-protein coupled receptor 34

Protein Summary

Description

Orphan receptor. G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

Uniprot Accession IDs

• Q9UPC5
• O95853

Gene Name

• GPR34

Ensembl ID

• ENST00000378138
• ENSP00000367378
• ENSG00000171659
• ENST00000378142
• ENSP00000367384
• ENST00000649219
• ENSP00000498130

Symbol

• LYPSR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.67
tissue sample	0.56
cell type or tissue	0.54
pathway	0.52
phenotype	0.47

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Probable G-protein Coupled Receptor 34

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Probable G-protein Coupled Receptor 34

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.12   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.12   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0