You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BSN
Protein bassoon

Protein Summary
Description
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296452
  • ENSP00000296452
  • ENSG00000164061

Symbol
  • KIAA0434
  • ZNF231
  • ZNF231
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.98
hub protein
0.85
histone modification site profile
0.81
cellular component
0.72
transcription factor
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.58   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.58   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
8.2
99.8
mathematical ability
4
3
4
99.7
intelligence
4
5
3
6.9
97.3
reticulocyte count
4
3
4
77.1
reticulocyte measurement
2
2
2
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
8.2
99.8
mathematical ability
4
99.7
intelligence
3
6.9
97.3
reticulocyte count
4
77.1
reticulocyte measurement
2
62.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bassoon presynaptic cytomatrix protein
VGNC:11328
460375
Macaque
bassoon presynaptic cytomatrix protein
705757
Mouse
MGI:1277955
12217
Rat
RGD:2223
29138
Dog
bassoon presynaptic cytomatrix protein
VGNC:54578
484769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bassoon presynaptic cytomatrix protein
Macaque
bassoon presynaptic cytomatrix protein
Mouse
Rat
Dog
bassoon presynaptic cytomatrix protein
Protein Structure (0 Structures, 14 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (162)
1 – 10 of 162
UNC13A
Tbio
Novelty: 0.01009835
Score: 0.91
Data Source: STRINGDB
RIMS1
Tbio
Novelty: 0.01126545
Score: 0.907
Data Source: STRINGDB
ERC1
Tbio
Novelty: 0.01251
Score: 0.856
Data Source: STRINGDB
ERC2
Tbio
Novelty: 0.00953771
Score: 0.799
Data Source: STRINGDB
UNC13B
Tbio
Novelty: 0.00429808
Score: 0.792
Data Source: STRINGDB
SYN1
Tbio
Novelty: 0.00093242
Score: 0.787
Data Source: STRINGDB
PPFIA3
Tbio
Novelty: 0.03837299
Score: 0.778
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.777
Data Source: STRINGDB
SYP
Tbio
Novelty: 0.00021543
Score: 0.769
Data Source: STRINGDB
SLC17A7
Tbio
Family: Transporter
Novelty: 0.00165722
Score: 0.768
Data Source: STRINGDB
Publication Statistics
PubMed Score  208.58

PubMed score by year
PubTator Score  54.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: