You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC12A4
Solute carrier family 12 member 4

Protein Summary
Description
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316341
  • ENSP00000318557
  • ENSG00000124067
  • ENST00000422611
  • ENSP00000395983
  • ENST00000537830
  • ENSP00000445962
  • ENST00000541864
  • ENSP00000438334
  • ENST00000576616
  • ENSP00000458902

Symbol
  • KCC1
  • KCC1
  • hKCC1
  • CTC-479C5.17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
co-expressed gene
0.94
transcription factor
0.89
disease perturbation
0.87
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.56   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.56   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0