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Tchem
PLA2G4C
Cytosolic phospholipase A2 gamma

Protein Summary
Description
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354276
  • ENSP00000346228
  • ENSG00000105499
  • ENST00000599111
  • ENSP00000472546
  • ENST00000599921
  • ENSP00000469473

Symbol
  • CPLA2-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.78
histone modification site profile
0.72
phenotype
0.69
virus perturbation
0.68
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.28   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.28   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (83)
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.825
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.825
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.825
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.825
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.822
Data Source:  STRINGDB
PLA2G16
Tchem
Novelty:  0.02310886
Score:  0.801
Data Source:  STRINGDB
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.793
Data Source:  STRINGDB
PNPLA7
Tdark
Family:  Enzyme
Novelty:  0.11025485
Score:  0.762
Data Source:  STRINGDB
PNPLA6
Tbio
Family:  Enzyme
Novelty:  0.00295195
Score:  0.756
Data Source:  STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
Score:  0.745
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (36)
Acyl chain remodelling of PC (R-HSA-1482788)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Glycerophospholipid biosynthesis
Reactome
Hydrolysis of LPC
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Glycerophospholipid biosynthesis
Hydrolysis of LPC
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
1
1
50.7
refractive error
1
1
1
35.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
50.7
refractive error
1
35.6
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 30.28
PubMed score by year
PubTator Score 21.97
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title