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Tchem
PLA2G4C
Cytosolic phospholipase A2 gamma

Protein Summary
Description
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354276
  • ENSP00000346228
  • ENSG00000105499
  • ENST00000599111
  • ENSP00000472546
  • ENST00000599921
  • ENSP00000469473

Symbol
  • CPLA2-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.78
histone modification site profile
0.72
phenotype
0.69
virus perturbation
0.68
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (36)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Glycerophospholipid biosynthesis
Reactome
Hydrolysis of LPC
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Glycerophospholipid biosynthesis
Hydrolysis of LPC
Gene Ontology Terms (26)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (83)
1 – 10 of 83
GNAS
Tbio
Novelty: 0.00284739
Score: 0.825
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.825
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.825
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.825
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.822
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.801
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.793
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.762
Data Source: STRINGDB
PNPLA6
Tbio
Family: Enzyme
Novelty: 0.00295195
Score: 0.756
Data Source: STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
Score: 0.745
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.64

PubMed score by year
PubTator Score  21.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer