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Tchem
FZD1
Frizzled-1

Protein Summary
Description
Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287934
  • ENSP00000287934
  • ENSG00000157240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
biological process
0.93
transcription factor binding site profile
0.83
protein domain
0.73
pathway
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.53   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.53   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (145)
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.991998196
p_ni:  2.84e-7
p_wrong:  0.00800152
Score:  0.191
Data Source:  BioPlex,STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.992
Data Source:  Reactome,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.989
Data Source:  Reactome,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.988
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.987
Data Source:  STRINGDB
WNT2
Tbio
Novelty:  0.00313614
Score:  0.985
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.985
Data Source:  STRINGDB
WNT3
Tchem
Novelty:  0.00498299
Score:  0.985
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.984
Data Source:  Reactome,STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.981
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
Pathways (68)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.2
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
33
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1196625
14362
Rat
RGD:61916
58868
Dog
frizzled class receptor 1
VGNC:41028
482294
Cow
frizzled class receptor 1
VGNC:29165
445417
Opossum
frizzled class receptor 1
100027981
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
frizzled class receptor 1
Cow
frizzled class receptor 1
Opossum
frizzled class receptor 1
Publication Statistics
PubMed Score 69.53
PubMed score by year
PubTator Score 44.43
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title