Tchem KCNJ14 ATP-sensitive inward rectifier potassium channel 14

Protein Summary

Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• Q9UNX9

Gene Name

• KCNJ14

Ensembl ID

• ENST00000342291
• ENSP00000341479
• ENSG00000182324
• ENST00000391884
• ENSP00000375756

Symbol

• IRK4
• IRK4
• KIR2.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
molecular function	0.84
tissue sample	0.74
virus perturbation	0.68
cellular component	0.57

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj14 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 11   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0