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Tchem
KCNJ14
ATP-sensitive inward rectifier potassium channel 14

Protein Summary
Description
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342291
  • ENSP00000341479
  • ENSG00000182324
  • ENST00000391884
  • ENSP00000375756

Symbol
  • IRK4
  • IRK4
  • KIR2.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.84
tissue sample
0.74
virus perturbation
0.68
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (30)
KCNQ5
Tclin
Family:  IC
Novelty:  0.01271842
Score:  0.87
Data Source:  STRINGDB
KCNQ3
Tclin
Family:  IC
Novelty:  0.00547886
Score:  0.824
Data Source:  STRINGDB
KCNQ2
Tclin
Family:  IC
Novelty:  0.00209684
Score:  0.821
Data Source:  STRINGDB
KCNJ12
Tchem
Family:  IC
Novelty:  0.00885141
Score:  0.81
Data Source:  Reactome,STRINGDB
KCNJ4
Tchem
Family:  IC
Novelty:  0.0093539
Score:  0.81
Data Source:  Reactome,STRINGDB
KCNJ2
Tchem
Family:  IC
Novelty:  0.00290395
Score:  0.808
Data Source:  Reactome,STRINGDB
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.806
Data Source:  STRINGDB
KCNQ4
Tclin
Family:  IC
Novelty:  0.00626926
Score:  0.803
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.8
Data Source:  STRINGDB
CCDC137
Tdark
Novelty:  1.16145052
Score:  0.632
Data Source:  STRINGDB
Pathways (9)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Classical Kir channels
Reactome
Inwardly rectifying K+ channels
Reactome
Muscle contraction
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Classical Kir channels
Inwardly rectifying K+ channels
Muscle contraction
Neuronal System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 14
VGNC:11144
468940
Macaque
potassium voltage-gated channel subfamily J member 14
718011
Mouse
MGI:2384820
211480
Rat
RGD:628872
276720
Cow
potassium voltage-gated channel subfamily J member 14
VGNC:30457
540740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 14
Macaque
potassium voltage-gated channel subfamily J member 14
Mouse
Rat
Cow
potassium voltage-gated channel subfamily J member 14
Publication Statistics
PubMed Score 17.88
PubMed score by year
PubTator Score 8.09
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title