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Tbio
WDR3
WD repeat-containing protein 3

Protein Summary
Description
This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349139
  • ENSP00000308179
  • ENSG00000065183

Symbol
  • DIP2
  • UTP12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
protein domain
0.85
kinase perturbation
0.81
cellular component
0.64
cell line
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (385)
WDR36
Tbio
Novelty:  0.02010676
p_int:  0.999999273
p_ni:  7.27e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999993834
p_ni:  0.000006166
Score:  0.904
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.999720395
p_ni:  0.000279349
p_wrong:  2.55e-7
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999639804
p_ni:  0.000360196
Data Source:  BioPlex
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.99665661
p_ni:  0.002756575
p_wrong:  0.000586815
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.994037418
p_ni:  0.005962315
p_wrong:  2.68e-7
Data Source:  BioPlex
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.993021325
p_ni:  0.006977978
p_wrong:  6.97e-7
Score:  0.671
Data Source:  BioPlex,STRINGDB
RRP9
Tbio
Novelty:  0.07232317
Score:  0.999
Data Source:  STRINGDB
NOP14
Tbio
Novelty:  0.08903014
Score:  0.999
Data Source:  STRINGDB
UTP6
Tbio
Novelty:  0.06525007
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
53.3
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 3
VGNC:1640
469436
Macaque
WD repeat domain 3
711960
Mouse
MGI:2443143
269470
Rat
RGD:1307480
310720
Dog
WD repeat domain 3
VGNC:48359
483143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 3
Macaque
WD repeat domain 3
Mouse
Rat
Dog
WD repeat domain 3
Publication Statistics
PubMed Score 8.50
PubMed score by year
PubTator Score 5.21
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title