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Tbio
CYP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Protein Summary
Description
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316161
  • ENSP00000318867
  • ENSG00000180432

Symbol
  • CYP12
  • CP8B
  • CYP12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.7
cell line
0.59
pathway
0.58
cellular component
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.43   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.43   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
4
5
95.3
myeloid white cell count
2
2
2
88.1
eosinophil count
3
1
3
83.6
eotaxin measurement
1
1
1
78.9
neutrophil count
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
95.3
myeloid white cell count
2
88.1
eosinophil count
3
83.6
eotaxin measurement
1
78.9
neutrophil count
1
78.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 8 subfamily B member 1
VGNC:6147
736962
Mouse
MGI:1338044
13124
Rat
RGD:71016
81924
Dog
cytochrome P450 family 8 subfamily B member 1
VGNC:50380
485619
Horse
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase
100054970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 8 subfamily B member 1
Mouse
Rat
Dog
cytochrome P450 family 8 subfamily B member 1
Horse
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UNU6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (44)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (93)
1 – 10 of 93
TACSTD2
Tbio
Novelty: 0.00297704
p_int: 0.999947778
p_ni: 0.000052209
p_wrong: 1.3e-8
Score: 0.689
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.993939225
p_ni: 0.006060775
Data Source: BioPlex
HERC3
Tbio
Family: Enzyme
Novelty: 0.05231675
p_int: 0.960744849
p_ni: 0.039255151
Score: 0.192
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.960016883
p_ni: 0.03997653
p_wrong: 0.000006587
Data Source: BioPlex
PTP4A2
Tchem
Family: Enzyme
Novelty: 0.0083639
p_int: 0.899308307
p_ni: 0.100562895
p_wrong: 0.000128798
Score: 0.187
Data Source: BioPlex,STRINGDB
HSD3B7
Tbio
Family: Enzyme
Novelty: 0.04791842
Score: 0.968
Data Source: STRINGDB
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
Score: 0.955
Data Source: STRINGDB
NR1H4
Tclin
Family: NR
Novelty: 0.00067092
Score: 0.814
Data Source: STRINGDB
ABCB11
Tchem
Family: Transporter
Novelty: 0.00097529
Score: 0.811
Data Source: STRINGDB
SQLE
Tchem
Family: Enzyme
Novelty: 0.0059338
Score: 0.805
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.43

PubMed score by year
PubTator Score  27.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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