ABCG2
ATP-binding cassette sub-family G member 2
Protein Classes
Protein Summary
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MR ...more
- ENST00000237612
- ENSP00000237612
- ENSG00000118777
- ENST00000515655
- ENSP00000426917
- ABCP
- BCRP
- BCRP1
- MXR
- MRX
- MXR
- ABCP
- BCRP
- BMDP
- MXR1
- ABC15
- BCRP1
- CD338
- GOUT1
- MXR-1
- CDw338
- UAQTL1
- EST157481
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
molecular function | 1 | ||
disease | 0.9 | ||
histone modification site profile | 0.86 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3773.63 (req: < 5)
Gene RIFs: 677 (req: <= 3)
Antibodies: 322 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3773.63 (req: >= 5)
Gene RIFs: 677 (req: > 3)
Antibodies: 322 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 192
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (192)
1 – 10 of 192
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
uric acid measurement | 12 | 7 | 17 | 1.9 | 99.9 | ||||
urate measurement | 10 | 6 | 15 | 10 | 99.8 | ||||
13 | 5 | 1 | 1.9 | 99.8 | |||||
C-reactive protein measurement | 2 | 2 | 2 | 94.4 | |||||
2 | 2 | 1 | 1.6 | 81.7 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
uric acid measurement | 17 | 1.9 | 99.9 | ||||
urate measurement | 15 | 10 | 99.8 | ||||
1 | 1.9 | 99.8 | |||||
C-reactive protein measurement | 2 | 94.4 | |||||
1 | 1.6 | 81.7 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily G member 2 | VGNC:2951 | 471251 | |||||
Macaque | ATP binding cassette subfamily G member 2 (Junior blood group) | 574307 | ||||||
Mouse | MGI:1347061 | 26357 | ||||||
Rat | RGD:631345 | 312382 | ||||||
Dog | ATP binding cassette subfamily G member 2 | VGNC:49113 | 478472 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily G member 2 | |||||
Macaque | ATP binding cassette subfamily G member 2 (Junior blood group) | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily G member 2 | |||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (5)
KEGG (3)
PathwayCommons (2)
WikiPathways (20)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Abacavir transmembrane transport | ||||
Reactome | Abacavir transport and metabolism | ||||
Reactome | Iron uptake and transport | ||||
Reactome | Metabolism | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Abacavir transmembrane transport | ||||
Abacavir transport and metabolism | ||||
Iron uptake and transport | ||||
Metabolism | ||||
Transport of small molecules | ||||
Gene Ontology Terms (19)
Functions (8)
Components (6)
Processes (5)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (224)
1 – 10 of 224
TRIM13
Family: Enzyme
Novelty: 0.00085649
p_int: 0.999953152
p_ni: 0.000046638
p_wrong: 2.1e-7
Data Source: BioPlex
SCAMP1
Novelty: 0.03293648
p_int: 0.969154338
p_ni: 0.030443828
p_wrong: 0.000401835
Data Source: BioPlex
CLPP
Family: Enzyme
Novelty: 0.00105289
p_int: 0.959667742
p_ni: 0.040332258
Data Source: BioPlex
CD55
Novelty: 0.0005689
p_int: 0.948557248
p_ni: 0.050592219
p_wrong: 0.000850534
Data Source: BioPlex
SLC19A2
Family: Transporter
Novelty: 0.00761796
p_int: 0.894884576
p_ni: 0.093234179
p_wrong: 0.011881244
Score: 0.177
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.89372036
p_ni: 0.10627964
Score: 0.199
Data Source: BioPlex,STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
p_int: 0.879097668
p_ni: 0.12090113
p_wrong: 0.000001202
Score: 0.403
Data Source: BioPlex,STRINGDB
ATP5F1B
Family: Enzyme
Novelty: 0.01053177
p_int: 0.813079889
p_ni: 0.186920111
Data Source: BioPlex
VTA1
Novelty: 0.01697854
p_int: 0.766115775
p_ni: 0.23384155
p_wrong: 0.000042675
Data Source: BioPlex
ABCC1
Family: Transporter
Novelty: 0.00119837
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score 3773.63
PubMed score by year
PubTator Score 2060.51
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait