Tchem ABCG2 ATP-binding cassette sub-family G member 2

Protein Summary

Description

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9UNQ0
• A0A1W3
• A8K1T5
• O95374
• Q4W5I3
• Q53ZQ1
• Q569L4
• Q5YLG4
• Q86V64
• Q8IX16
• Q96LD6
• Q96TA8
• Q9BY73
• Q9NUS0

Gene Name

• ABCG2

Ensembl ID

• ENST00000237612
• ENSP00000237612
• ENSG00000118777
• ENST00000515655
• ENSP00000426917

Symbol

• ABCP
• BCRP
• BCRP1
• MXR
• MRX
• MXR
• ABCP
• BCRP
• BMDP
• MXR1
• ABC15
• BCRP1
• CD338
• GOUT1
• MXR-1
• CDw338
• UAQTL1
• EST157481

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
drug	1
molecular function	1
disease	0.9
histone modification site profile	0.86

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family G Member 2

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcg Subfamily / Atp-binding Cassette Sub-family G Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4276.67   (req: < 5)

Gene RIFs: 796   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4276.67   (req: >= 5)

Gene RIFs: 796   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 658

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6