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Tchem
ABCG2
ATP-binding cassette sub-family G member 2

Protein Summary
Description
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237612
  • ENSP00000237612
  • ENSG00000118777
  • ENST00000515655
  • ENSP00000426917

Symbol
  • ABCP
  • BCRP
  • BCRP1
  • MXR
  • MRX
  • MXR
  • ABCP
  • BCRP
  • BMDP
  • MXR1
  • ABC15
  • BCRP1
  • CD338
  • GOUT1
  • MXR-1
  • CDw338
  • UAQTL1
  • EST157481
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
1
disease
0.9
histone modification site profile
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3773.63   (req: < 5)
Gene RIFs: 677   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3773.63   (req: >= 5)
Gene RIFs: 677   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 192
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (192)
1 – 10 of 192
CHEMBL3582149
chemical structure image
CHEMBL3582156
chemical structure image
CHEMBL3582155
chemical structure image
CHEMBL3582167
chemical structure image
CHEMBL3582168
chemical structure image
CHEMBL2335002
chemical structure image
CHEMBL428402
chemical structure image
CHEMBL348475
chemical structure image
CHEMBL247473
chemical structure image
CHEMBL3809802
chemical structure image
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
12
7
17
1.9
99.9
urate measurement
10
6
15
10
99.8
13
5
1
1.9
99.8
C-reactive protein measurement
2
2
2
94.4
2
2
1
1.6
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
17
1.9
99.9
urate measurement
15
10
99.8
1
1.9
99.8
C-reactive protein measurement
2
94.4
1
1.6
81.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 2
VGNC:2951
471251
Macaque
ATP binding cassette subfamily G member 2 (Junior blood group)
574307
Mouse
MGI:1347061
26357
Rat
RGD:631345
312382
Dog
ATP binding cassette subfamily G member 2
VGNC:49113
478472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily G member 2
Macaque
ATP binding cassette subfamily G member 2 (Junior blood group)
Mouse
Rat
Dog
ATP binding cassette subfamily G member 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UNQ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Abacavir transmembrane transport (R-HSA-2161517)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir transmembrane transport
Reactome
Abacavir transport and metabolism
Reactome
Iron uptake and transport
Reactome
Metabolism
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Abacavir transmembrane transport
Abacavir transport and metabolism
Iron uptake and transport
Metabolism
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (224)
1 – 10 of 224
TRIM13
Tbio
Family: Enzyme
Novelty: 0.00085649
p_int: 0.999953152
p_ni: 0.000046638
p_wrong: 2.1e-7
Data Source: BioPlex
SCAMP1
Tbio
Novelty: 0.03293648
p_int: 0.969154338
p_ni: 0.030443828
p_wrong: 0.000401835
Data Source: BioPlex
CLPP
Tbio
Family: Enzyme
Novelty: 0.00105289
p_int: 0.959667742
p_ni: 0.040332258
Data Source: BioPlex
CD55
Tbio
Novelty: 0.0005689
p_int: 0.948557248
p_ni: 0.050592219
p_wrong: 0.000850534
Data Source: BioPlex
SLC19A2
Tbio
Family: Transporter
Novelty: 0.00761796
p_int: 0.894884576
p_ni: 0.093234179
p_wrong: 0.011881244
Score: 0.177
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.89372036
p_ni: 0.10627964
Score: 0.199
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.879097668
p_ni: 0.12090113
p_wrong: 0.000001202
Score: 0.403
Data Source: BioPlex,STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
p_int: 0.813079889
p_ni: 0.186920111
Data Source: BioPlex
VTA1
Tbio
Novelty: 0.01697854
p_int: 0.766115775
p_ni: 0.23384155
p_wrong: 0.000042675
Data Source: BioPlex
ABCC1
Tchem
Family: Transporter
Novelty: 0.00119837
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  3773.63

PubMed score by year
PubTator Score  2060.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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