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Tbio
ST3GAL5
Lactosylceramide alpha-2,3-sialyltransferase

Protein Summary
Description
Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393805
  • ENSP00000377394
  • ENSG00000115525
  • ENST00000393808
  • ENSP00000377397
  • ENST00000638572
  • ENSP00000491316
  • ENST00000638986
  • ENSP00000491853
  • ENST00000639432
  • ENSP00000491828
  • ENST00000640322
  • ENSP00000491564
  • ENST00000640982
  • ENSP00000492299
  • ENST00000640992
  • ENSP00000492753

Symbol
  • SIAT9
  • SATI
  • SIAT9
  • SPDRS
  • ST3GalV
  • SIATGM3S
  • ST3Gal V
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.88
small molecule perturbation
0.84
cellular component
0.76
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.44   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.44   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
77.1
red blood cell distribution width
1
1
1
58.4
mean platelet volume
2
1
2
44.7
mean corpuscular volume
1
1
1
20
monocyte percentage of leukocytes
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
77.1
red blood cell distribution width
1
58.4
mean platelet volume
2
44.7
mean corpuscular volume
1
20
monocyte percentage of leukocytes
1
2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
VGNC:10300
459371
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
696842
Mouse
MGI:1339963
20454
Rat
RGD:620875
83505
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
VGNC:46853
612022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Mouse
Rat
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UNP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (81)
1 – 10 of 81
NDUFAF7
Tbio
Family: Enzyme
Novelty: 0.24691414
p_int: 0.932506878
p_ni: 0.067420956
p_wrong: 0.000072167
Score: 0.252
Data Source: BioPlex,STRINGDB
TMEM259
Tbio
Novelty: 0.10015777
p_int: 0.75081207
p_ni: 0.249187926
p_wrong: 4e-9
Score: 0.292
Data Source: BioPlex,STRINGDB
B4GALNT1
Tbio
Family: Enzyme
Novelty: 0.01060447
Score: 0.971
Data Source: STRINGDB
ST8SIA1
Tbio
Family: Enzyme
Novelty: 0.02322808
Score: 0.964
Data Source: STRINGDB
HEXB
Tchem
Family: Enzyme
Novelty: 0.0085045
Score: 0.915
Data Source: STRINGDB
HEXA
Tchem
Family: Enzyme
Novelty: 0.01134783
Score: 0.913
Data Source: STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00241713
Score: 0.897
Data Source: STRINGDB
B4GALT6
Tbio
Family: Enzyme
Novelty: 0.08523889
Score: 0.88
Data Source: STRINGDB
MAN2A1
Tbio
Family: Enzyme
Novelty: 0.03034058
Score: 0.73
Data Source: STRINGDB
B4GALNT2
Tbio
Family: Enzyme
Novelty: 0.00499206
Score: 0.723
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.44

PubMed score by year
PubTator Score  75.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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