Tbio ST3GAL5 Lactosylceramide alpha-2,3-sialyltransferase

Protein Summary

Description

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UNP4
• B3KM82
• D6W5L9
• O94902
• Q53QU1
• Q6NZX4
• Q6YFL1

Gene Name

• ST3GAL5

Ensembl ID

• ENST00000393805
• ENSP00000377394
• ENSG00000115525
• ENST00000393808
• ENSP00000377397
• ENST00000638572
• ENSP00000491316
• ENST00000638986
• ENSP00000491853
• ENST00000639432
• ENSP00000491828
• ENST00000640322
• ENSP00000491564
• ENST00000640982
• ENSP00000492299
• ENST00000640992
• ENSP00000492753

Symbol

• SIAT9
• SATI
• SIAT9
• SPDRS
• ST3GalV
• SIATGM3S
• ST3Gal V

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
transcription factor binding site profile	0.88
small molecule perturbation	0.84
cellular component	0.76
histone modification site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.43   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.43   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0