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Tbio
PROCR
Endothelial protein C receptor

Protein Summary
Description
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216968
  • ENSP00000216968
  • ENSG00000101000

Symbol
  • EPCR
  • CCCA
  • EPCR
  • CCD41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
biological term
0.86
trait
0.86
cellular component
0.83
gene perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 673.45   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 505   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 673.45   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 505   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.953730705
p_ni:  0.046269295
p_wrong:  1e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.855937716
p_ni:  0.144060865
p_wrong:  0.000001419
Score:  0.167
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.839404281
p_ni:  0.160583904
p_wrong:  0.000011815
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.762802835
p_ni:  0.237197145
p_wrong:  2.1e-8
Score:  0.328
Data Source:  BioPlex,STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.994
Data Source:  Reactome,STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.99
Data Source:  Reactome,STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.989
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.96
Data Source:  Reactome,STRINGDB
PROS1
Tbio
Novelty:  0.00275184
Score:  0.953
Data Source:  STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.932
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
3
3
6
99.3
4
6
2
1.1
98.7
factor VII measurement
2
3
4
98.4
prothrombin time measurement
2
2
2
96
appendicular lean mass
2
10
10
94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
6
99.3
2
1.1
98.7
factor VII measurement
4
98.4
prothrombin time measurement
2
96
appendicular lean mass
10
94
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein C receptor
VGNC:6249
458198
Mouse
MGI:104596
19124
Rat
RGD:1305991
362248
Dog
protein C receptor
VGNC:45008
485848
Horse
protein C receptor
VGNC:21871
100069445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein C receptor
Mouse
Rat
Dog
protein C receptor
Horse
protein C receptor
Publication Statistics
PubMed Score 673.45
PubMed score by year
PubTator Score 354.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title